Registration Dossier
Registration Dossier
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EC number: 201-143-3 | CAS number: 78-79-5
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- See QMRF document in cross-reference.
Cross-reference
- Reason / purpose for cross-reference:
- (Q)SAR model reporting (QMRF)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The QSAR Toolbox version 4.3.1 was used to assess skin sensitisation potential
Test material
- Reference substance name:
- Isoprene
- EC Number:
- 201-143-3
- EC Name:
- Isoprene
- Cas Number:
- 78-79-5
- Molecular formula:
- C5H8
- IUPAC Name:
- 2-methylbuta-1,3-diene
Constituent 1
Results and discussion
In vitro / in chemico
Results
- Remarks on result:
- no indication of skin sensitisation
Any other information on results incl. tables
Protein binding alerts for skin sensitization according to GHS - No alerts found
Protein binding alerts for skin sensitization by OASIS - No alerts found
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Protein binding alerts for skin sensitization according to GHS - No alerts found
Protein binding alerts for skin sensitization by OASIS - No alerts found
These (Q)SAR results indicate that isoprene should be "not classified" for skin sensitisation - Executive summary:
Protein binding alerts for skin sensitization according to GHS - No alerts found
Protein binding alerts for skin sensitization by OASIS - No alerts found
These (Q)SAR results indicate that isoprene should be "not classified" for skin sensitisation
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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