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EC number: 248-122-5 | CAS number: 26942-95-0
ACTUAL DOSE RECEIVED
test group 2: 516 mg/kg bw
test group 3: 5015 mg/kg bw
test group 4: 5063 mg/kg bw
The mean 14C-radioactivity administered was:
test group 2: 8.45 µCi/animal
test group 3: 6.52 µCi/animal
test group 4: 5.93 µCi/animal
The slightly lower than targeted levels (10 µCi/animal) administered to animals was considered not to impact the outcome of the study since rats were dosed similar amounts of labelled and unlabelled test articles per kg of body weight.
No treatment related clinical signs were observed in animals prior to or subsequent to treatment with the test item.
The recovery from the extraction of the gastrointestinal tract and contents, the liver and the blood was less than 50%. Thus, the radioactivity was associated mainly with water-soluble material. Additionally, the recovery in the blood was lower than 10%. One animal in group 3 showed a recovery of 60.7% in the gastrointestinal tract and contents at 1 hour post-dose. For the perirenal fat, the radioactivity was associated mainly with fat-soluble material.
Thin layer chromatography of organic extracts 1 hour after dosing demonstrated an association of the radioactivity in the gastrointestinal tract and contents with free fatty acids for the low and high-dose group. Further, 12 and 24 hours post-dosing, the radioactivity in the gastrointestinal tract and contents for the high-dose group was mostly associated with diacylglycerides.
Liver extracts revealed an association of the radioactivity with cholesterol for group 3 animals in samples isolated 6 h after administration. However, the exact nature of the main component retained on the origin could not be determined although it was determined for the standards that phospholipids also had an Rf value of 0. In one animal of the low dose group, more than 70% of the radioactivity in the blood extract was cholesterol whereas another animal of the same dose group showed background levels of the radioactivity in the blood extracts. For perirenal fat, the radioactivity in the extracts was also at background level.
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