Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 293-263-8 | CAS number: 91053-01-9 A complex combination of hydrocarbons obtained from distillation of the butadiene-free C4 fraction of a naphtha steam-cracking process. It consists predominantly of olefinic hydrocarbons having carbon numbers of C8, C12, C16 and C20 and boiling in the range of approximately 170°C to 185°C (338°F to 365°F).
Carcinogenicity
Administrative data
Description of key information
On the basis of the available evidence it can be concluded that butylene oligomers are not genotoxic and are unlikely to be carcinogenic
Key value for chemical safety assessment
Justification for classification or non-classification
There is no data to suggest that classification of butylene oligomers is warranted under DSD or CLP.
Additional information
There are no carcinogenicity studies for the butylene oligomers category members.
Butylene oligomers are simple olefins that do not carry alerts for genotoxic activity.
Butylene oligomers have been tested in a number of well recognised assays for genotoxicity and have shown no significant genotoxic activity in vitro and in vivo. In vitro assays comprise six bacterial reverse mutation assays with olefins ranging from C8 to C20/24 and two mammalian chromosome aberration tests with C8. In vivo mutagenicity assays comprise four mammalian erythrocyte micronucleus tests in the mouse or the rat covering three different routes of administration oral, inhalation and intraperitoneal and olefins ranging from C8 to C20/C24. The results are consistent throughout the category and indicate that butylene oligomers are not expected to be genotoxic carcinogens.
Repeat dose toxicity studies with higher olefins spanning the range C8 to C20 indicate that these materials are of low toxicity in rats. There is a consistent finding of male rat kidney effects indicative of alpha-2u-globulin nephropathy with the C8 to C14 higher olefins. Although α2u-Globulin has been associated with chemically induced renal toxicity and neoplasia in the male rat, the nephropathy is a syndrome that occurs exclusively in male rat kidney and is not relevant for humans.
There is no evidence of target organ toxicity or pre-neoplastic changes in repeated dose studies with butylene oligomers which suggest that they are likely to be genotoxic.
Hard GC, Rodgers IS, Baetcke KP, Richards WL, McGaughy RE, and Valcovic LR (1993)Environ Health Perspect.1993 March;99: 313–349.Hazard evaluation of chemicals that cause accumulation of alpha 2u-globulin, hyaline droplet nephropathy, and tubule neoplasia in the kidneys of male rats.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
