glyoxal … %; ethandial … %

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Scientifically acceptable

Data source

Reference

Reference Type:

publication

Title:

Occupational contact allergy to glyoxal.

Author:

Aalto-Korte K, Mäkelä EA, Huttunen M, Suuronen K, Jolanki R

Year:

2005

Bibliographic source:

Contact Dermatitis 52(5): 276-281

Materials and methods

Type of study / information:

Type of experience: other: occupational contact allergy

Test material

Test material information

Constituent 1

Reference substance name:

Glyoxal

EC Number:

203-474-9

EC Name:

Glyoxal

Cas Number:

107-22-2

Molecular formula:

C2H2O2

IUPAC Name:

oxalaldehyde

Test material form:

liquid

Results and discussion

Any other information on results incl. tables

Irritation and doubful skin reactions: In the group of 614 patients, 91 cases (i.e 14.9%) of irritation or doubtful reactions were noticed, with a reation index of -0.78. In the 1% aqueous glyoxal solution and the 1% glyoxal trimer solution in pet., reation indices of -0.5 and 0 were calculated, respectively.   Allergic reactions: Twenty patients (i.e. 2.2%) were found to be allergic to glyoxal. Nine of these patients (i.e. 45%) also were allergic to formaldehyde and glutaraldehyde. Occupational background: Five of the positive patients worked in dentistry and 4 of them had present exposure to glyoxal. Nine patients were machinists without obvious exposure to glyoxal. One patient was a grinder with work-related facial dermatitis. The remaining 6 patients worked in miscellaneous occupations and had no present exposure to glyoxal.  Diagnosis: The diagnosis was occupational allergic or irritant contact hand dermatitis.