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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Scientifically acceptable

Data source

Reference
Reference Type:
publication
Title:
Occupational contact allergy to glyoxal.
Author:
Aalto-Korte K, Mäkelä EA, Huttunen M, Suuronen K, Jolanki R
Year:
2005
Bibliographic source:
Contact Dermatitis 52(5): 276-281

Materials and methods

Type of study / information:
Type of experience: other: occupational contact allergy

Test material

Constituent 1
Chemical structure
Reference substance name:
Glyoxal
EC Number:
203-474-9
EC Name:
Glyoxal
Cas Number:
107-22-2
Molecular formula:
C2H2O2
IUPAC Name:
oxalaldehyde
Test material form:
liquid

Results and discussion

Any other information on results incl. tables

Irritation and doubful skin reactions: In the group of 614 patients, 91 cases (i.e 14.9%) of irritation or doubtful reactions were noticed, with a reation index of -0.78. In the 1% aqueous glyoxal solution and the 1% glyoxal trimer solution in pet., reation indices of -0.5 and 0 were calculated, respectively.   Allergic reactions: Twenty patients (i.e. 2.2%) were found to be allergic to glyoxal. Nine of these patients (i.e. 45%) also were allergic to formaldehyde and glutaraldehyde. Occupational background: Five of the positive patients worked in dentistry and 4 of them had present exposure to glyoxal. Nine patients were machinists without obvious exposure to glyoxal. One patient was a grinder with work-related facial dermatitis. The remaining 6 patients worked in miscellaneous occupations and had no present exposure to glyoxal.  Diagnosis: The diagnosis was occupational allergic or irritant contact hand dermatitis.

Applicant's summary and conclusion

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