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EC number: 203-474-9 | CAS number: 107-22-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- The test method was comparable to the limit test as described by OECD guideline 402 (1987) without GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- ((limit test, 1987)
- GLP compliance:
- no
- Remarks:
- the study was carried out in a GLP certified laboratory. However, the study was not monitored by the QAU; therefore, the study was not fully compliant to GLP requirements.
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Glyoxal
- EC Number:
- 203-474-9
- EC Name:
- Glyoxal
- Cas Number:
- 107-22-2
- Molecular formula:
- C2H2O2
- IUPAC Name:
- oxalaldehyde
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Tank B 401
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Stability under test conditions: Glyoxal as 40% aqueous solution is stable for 6 months
OTHER
- Impurities (identity and concentrations): ethylene glycol, glycol aldehyde, formaldehyde, formic acid, glycolic acid, glyoxylic acid)
- Composition of test material, percentage of components: Glyoxal 40%, ethylene glycol 0.6%, glycol aldehyde 0.15%, formaldehyde 0.015%, formic acid, glycolic acid, glyoxylic acid, 0.1%)
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH, D-7950 Biberach, Germany
- Weight at study initiation:
mean body weight of the males: 269 g
mean body weight of the females: 227 g
- Fasting period before study: no
- Housing: single housing in steel wire mesh cages, type OK-III (Becker & co. Castrop-Rauxel, Germany)
- Diet (e.g. ad libitum): Kliba-Labordiaet, FA. Klingentalmuehle AG, CH-4303 Kaiseraugst, Switzerland, ad libitum
- Water (e.g. ad libitum): Tap water, ad libitum
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Air changes (per hr): housing in fully air-conditioned rooms
- Photoperiod (hrs dark / hrs light): 12 h/ 12 h
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- water
- Details on dermal exposure:
- Each animal received a single application of unchanged test substance on the clipped skin within the dorsal to dorsolateral region of the trunk; clipping of the fur had been done at least 15 hours prior to treatment. The application volume was 1.57 mL/kg bw and the tested dose level was 2000 mg/kg bw. The application site was covered with a semiocclusive dressing for 24 hours; thereafter, dressing was removed and the application site was rinsed with warm water.
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 10 animals/sex/group were used
- Control animals:
- no
- Details on study design:
- - The treatment was followed by a 14-day post -exposure period of observation;
- The animals were observed for mortality twice each workday and once daily at weekends or public holidays;
- They were examined for clinical symptoms of toxicity several times during the application day and at least once daily thereafter;
- Skin findings were scored 30 to 60 minutes following removal of the dressing, and at least once weekly during the observation period;
- The rats were weighed prior treatment and thereafter, on day 2, 7 and 13 post-treatment;
- At the end of the observation period, the surviving animals were sacrificed for the purpose of necropsy;
- Animals that died during the observations period also were subjected to necropsy.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Neither mortality nor symptoms of toxicity were seen at the tested dose level of 2000 mg/kg bw.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 800 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: Neither mortality nor symptoms of toxicity were seen at the tested dose level of 2000 mg/kg bw of test material Glyoxal 40%, i.e., 800 mg/kg bw of the active ingredient.
- Mortality:
- No mortalities were observed.
- Clinical signs:
- other: No clinical symptoms of toxicity were observed.
- Gross pathology:
- All animals survived and were sacrificed at the end of the observation period; necropsy revealed no abnormalities.
- Other findings:
- Skin examination revealed erythema in both males and females on day 1 following treatment.
Any other information on results incl. tables
Body weight data:
Time point of body weight recording |
Males (mean body weight, N = 5) |
Females (mean body weight, N = 5) |
Initial |
269 g |
227 g |
Day 2 |
253 g |
218 g |
Day 7 |
278 g |
230 g |
Day 13 |
347 g |
240 g |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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