Registration Dossier
Registration Dossier
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EC number: 292-997-6 | CAS number: 91031-91-3
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility (< 0.05 mg/L) based on available data (OECD 203).
Key value for chemical safety assessment
Additional information
Since no studies investigating the short-term toxicity of fatty acids, coco, isotridecyl esters (CAS 91031-91-3) to fish are available for this endpoint, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the two structurally most similar category members tetradecyl myristate (CAS 3234-85-3) and Fatty acids, C8 - 10, C12 - 18-alkyl esters (CAS 95912-86-0) was conducted. This read-across is justified in detail in the overall summary (IUCLID chapter 6.1) and within the category justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. The read-across substance Tetradecyl myristate is covering the upper end, whereas the read-across substance Fatty acids, C8 - 10, C12 - 18-alkyl esters covers the lower end of fatty acid and fatty alcohol chain lengths. The available data allow interpolation to fatty acids, coco, isotridecyl esters. As it can be seen in the data matrix of the category justification in section 13 and the overall summary, all reliable data in the category support the hazard assessment of each category member by showing a consistent pattern of results.
The first study was performed according to OECD 203 (GLP) and investigated the short-term toxicity of tetradecyl myristate (CAS 3234-85-3) to freshwater fish (Teigeler, 2012).The zebra fish Danio rerio was exposed for 96 h to a limit Water Accommodated Fraction (WAF) concentration of nominal 100 mg/L.GC/EI-MS analysis resulted in a measured initial concentration of 0.189 µg/L which dropped below the detection limit of 0.1 µg/L at the end of exposure after 96 h. No mortality was observed resulting in a LL50 of > 0.189 µg/L (measured initial concentration) and > 100 mg/L (nominal), respectively. The second study with the read-across substance Fatty acids, C8 - 10, C12 - 18-alkyl esters (CAS 95912-86-0) was performed according to OECD 203 (GLP; Salinas 2013). Danio rerio was exposed to a nominal concentration of 100 mg/L for 96 h (Water Accommodated Fraction). No mortality was observed after 96 h of incubation resulting in a LL50 (96 h) > 100 mg/L (nominal) and a NOELR (96 h) ≥ 100 mg/L (nominal). Based on the available result from one structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that fatty acids, coco, isotridecyl esters will not exhibit short-term effects to fish up to the limit of water solubility.
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