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Short-term toxicity to aquatic invertebrates

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Description of key information

No effects up to the limit of water solubility (< 0.05 mg/L) based on available data (OECD 202).

Key value for chemical safety assessment

Additional information

Since no studies investigating the short-term toxicity of fatty acids, coco, isotridecyl esters (CAS 91031-91-3) to aquatic invertebrates are available for this endpoint, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the one structurally most similar category member tetradecyl myristate (CAS 3234-85-3) was conducted. This read-across is justified in detail in the overall summary (IUCLID chapter 6.1) and within the category justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. Tetradecyl myristate is characterized by similar fatty acid (C14 compared to C12-C14 (target)) and fatty alcohol (C14 compared to C12(target)) chain lengths. As it can be seen in the data matrix of the category justification in section 13 and the overall summary, all reliable data in the category support the hazard assessment of each category member by showing a consistent pattern of results.

The study with the read-across substance tetradecyl myristate (CAS 3234-85-3) was conducted according to OECD 202 (GLP) and investigated the short-term effects to freshwater invertebrates (Schlechtriem, 2012). Daphnia magna was exposed to a Water Accommodated Fraction (WAF) of nominal 100 mg/L in a limit test for 48 h. GC/EI-MS analysis resulted in a measured geometric mean concentration of 0.128 µg/L. No immobilization was recorded after 48 h resulting in an EL50 of > 0.128 µg/L (measured, geometric mean) and > 100 mg/L (nominal), respectively.

Based on the available results from one structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that fatty acids, coco, isotridecyl esters will not exhibit short-term effects to aquatic invertebrates up to the limit of water solubility.

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