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Short-term toxicity to aquatic invertebrates

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Description of key information

The acute toxicity of C8 -18 and C18 unsatd. AAPB to Daphnia magna was investigated in four studies conducted according to OECD guideline 202. The study with the lowest 48 h EC50 was selected as key study. Additional data were available for C8-18 AAPB from an OECD 202 guideline study with Daphnia magna. The acute toxicity of Coco AAPB to the marine copepod Acartia tonsa was investigated in a study conducted according to ISO 14669 (1999) Water 
Quality - Determination of the acute lethal toxicity to marine capepods (Copepoda; Crustacea).

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Dose descriptor:
EC50
Effect concentration:
1.9 mg/L

Marine water invertebrates

Marine water invertebrates
Dose descriptor:
EC50
Effect concentration:
7 mg/L

Additional information

Reliable results on the acute toxicity of C8-18 and C18 unsatd. AAPB (Coco AAPB) to fresh water and salt water invertebrates obtained in guideline studies are available.

Further data on the acute toxicity to fresh water invertebrates are available for the closely related substances C12 AAPB and C8-18 AAPB.

 

Freshwater invertebrates

The acute toxicity of Coco AAPB toDaphnia magnawas investigated in a study conducted according to OECD TG 202 / part I (1984) under static conditions.Daphnia magnawas exposed to 6 nominal concentrations ranging from 0.5 to 16 mg product/L. A 48 h LC50 of ca. 1.9 mg a.i/L (nominal) was determined based on an active matter content of 30%.

 

The 48 hr-acute toxicity of C8-18 AAPB (30% active matter) toDaphnia magnawas investigated in a study conducted according to OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) and EU Method C.2 (Acute Toxicity for Daphnia) under static conditions. Daphnids were exposed to control and test chemical at nominal concentrations of 6.25; 12.5; 25; 50; 100 mg product/L for 48 hr. The test material concentrations were analysed via UV absorption at 485 nm. The C8-18 AAPB concentrations were >80% (exception: 72.2% at the start in the 6.25 mg product/L group). The 48 h EC50 was determined to be 6.5 mg a.i./L based on nominal concentrations.

 

A study on the acute toxicity of C12 AAPB to Daphnia magna was conducted according to OECD Guideline 202 (April 2004). The daphnids (20/concentration) were exposed to nominal concentrations of 0 (control),11.6, 25.5, 56.2, 124 and 272 mg test item/L, which correspond to the following concentrations of 4.27, 9.39, 20.7, 45.5 and 100 mg solids/ L, for 48 h under semi-static conditions.

The measured concentrations ranged between 112–117% of the nominal concentrations at the middle and highest treatment level throughout the test. No biological effects were observed at the three lower concentrations. The lowest test concentration showed similar ranges from 121–126% of the nominal concentrations but was slightly higher than the required 120% limit of the nominal concentration throughout the test period.

Since the measured test item concentrations were stable during the test period between 98 and 101% of the measured initial concentrations and the overall recovery of the measured concentrations was 118% of the nominal concentrations, the biological results are calculated and reported based on nominal concentrations.

A clear concentration-response relationship was observed. The following EC50 value was determined:

48 h EC50 = 124 mg test item/L, corresponding to 45.6 mg solids/L

 

Two further supporting studies are available:

The acute toxicity of Coco AAPB to Daphnia magna was investigated in a study conducted according to OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) and EU Method C.2 (Acute Toxicity for Daphnia). The daphnids were exposed to nominal concentrations of 0 (control), 0.56, 1.0, 1.8, 3.2, 5.6, and 10.0 mg a.i./L for 48 h under semi-static conditions (renewal of the test solutions after 24 h). The 48 h EC50 was found to be 4.1 mg a.i./L (nominal).

 

The 48-hr-acute toxicity of Coco AAPB to Daphnia magna was investigated in a study conducted according to EU Method C.2 (Acute Toxicity for Daphnia) under static conditions. Daphnids were exposed to control and test chemical at (nominal/measured) concentration of 3.5; 6; 10; 17; 30 mg dry residue/L for 48 hr. Immobilization were observed. The 48 h EC50 was 6.6 mg a.i./L nominal.

 

Marine invertebrates

The acute toxicity of Coco AAPB to the marine copepod Acartia tonsa was investigated in a study conducted according to ISO 14669 (1999) Water Quality - Determination of the acute lethal toxicity to marine capepods (Copepoda; Crustacea). Acartia tonsa were exposed to nominal Coco AAPB static conditions for 48 h. The 48 h NOEC and LC50 values were determined to be 3.6 mg a. i./L and 7.0 mg a.i./L nominal, respectively. The 48 h LC50 of 7.0 mg a i./L nominal was used for further assessment.

 

Conclusion

For freshwater invertebrates (Daphnia magna) the lowest 48 h EC50 was determined to be 1.9 mg a. i./L (nominal), and for the marine copepod Acartia tonsa  the 48 h EC50 was 7.0 mg a.i./L (nominal).