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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation of the study is insufficient for assessment. Tthe amount of antimony trioxide is not known and no control animals was used.
Reason / purpose for cross-reference:
reference to same study

Data source

Reference Type:
study report

Materials and methods

Test guideline
no guideline followed
Principles of method if other than guideline:
No guideline specified at the time of conduct.
In this briefly reported study the toxicity of a polythene composition containing antimony trioxide (polythene + 0.2% “Akroflex” C/ antimony trioxide/“Chlorowax”) was tested.
(2) doses which varied between 600 - 1000 mg/kg/day were fed to 6 guinea pigs for 5d/wk for a total of 10 treatments.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Flame Resistant Polythene Composition
Flame Resistant Polythene Composition
Details on test material:
- Name of test material (as cited in study report): Polythene composition JRP-10083-B (polythene + 0.2%"Akroflex" C / antimony trioxide /
"Chlorowax" 70 57/20/15)
- Substance type: formulation
- Composition of test material, percentage of components: polythene + 0.2% “Akroflex” C/ antimony trioxide/ “Chlorowax”
- no other details on test material stated

Test animals

guinea pig
not specified
not specified

Administration / exposure

Route of administration:
oral: feed
Details on oral exposure:
- not stated
varied between 600 - 1000 mg/kg/day for 5 days/wk and total of 10 treatments
No. of animals per sex per dose:
6 guinea pigs
Control animals:

Results and discussion

Effect levels
Remarks on result:
other: Study documentation is insufficient for assessment e.g. number of animals not stated.
no mortality
Gross pathology:
gross and micropathological examination did not show any organic damage attributable to the substrate

Applicant's summary and conclusion

This study is regarded as invalid and will not be used for the risk assessment of diantimony trioxide, due to the fact that the extract was not analysed and the amount of diantimony trioxide not known, the number of animals included in the study was not stated and no control animals was used.