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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
no data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study did not follow any guideline and was not performed according to GLP. Route is i.p. Limited reporting.

Data source

Reference
Reference Type:
publication
Title:
Antidotes for zinc intoxication in mice
Author:
Llobet, J.M., Domingo. J.L., Corbella, J.
Year:
1988
Bibliographic source:
Arch Toxicol. 61 : 321 -323

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Sixteen chelating agents were examined to determine their relative efficacy as antidotes in acute zinc acetate intoxication in mice after i.p. administration.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Amines, polyethylenepoly-, triethylenetetramine fraction
EC Number:
292-588-2
EC Name:
Amines, polyethylenepoly-, triethylenetetramine fraction
Cas Number:
90640-67-8
Molecular formula:
C6H18N4, C8H20N4
IUPAC Name:
(2-aminoethyl)({2-[(2-aminoethyl)amino]ethyl})amine; tris(2-aminoethyl)amine
Test material form:
liquid
Specific details on test material used for the study:
Named in the report: triethylenetetramine (TTHA)
substance was obtained from Sigma Chemical Company (St. Louis, Mo., USA)

Test animals

Species:
mouse
Strain:
Swiss
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: 0.9% saline

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
3.2 other: mmol/kg
Based on:
test mat.
Remarks on result:
other: i.p.

Applicant's summary and conclusion

Conclusions:
The LD50 of the test substance via the intraperitoneal route was indicated to be 3.2 mmol/kg bw.
Executive summary:

Sixteen chelating agents were examined to determine their relative efficacy as antidotes in acute zinc acetate intoxication in mice after i.p. administration. The test substance was not effective at all. It was indicated in this paper that the ip LD50 of the test substance was 3.2 mmol/kg bw (no further details given).