Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

Endpoint:
basic toxicokinetics in vivo
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary literature, but generally accepted source. Taken from OECD SIDS on Sodium bicarbonate (2002).

Data source

Reference
Reference Type:
publication
Title:
Proposed rules. Carbonates and bicarbonates. Proposed affirmation of GRAS status as direct and indirect human food ingredients
Author:
Food and Drug Administration,
Year:
1978
Bibliographic source:
Federal Register, vol. 43, no. 114, p52440-52443

Materials and methods

Objective of study:
toxicokinetics
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium hydrogencarbonate
EC Number:
205-633-8
EC Name:
Sodium hydrogencarbonate
Cas Number:
144-55-8
Molecular formula:
CH2O3.Na
IUPAC Name:
sodium hydrogen carbonate

Test animals

Species:
mouse

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified

Results and discussion

Toxicokinetic / pharmacokinetic studies

Toxicokinetic parametersopen allclose all
Toxicokinetic parameters:
half-life 2nd:
Toxicokinetic parameters:
half-life 1st:
Toxicokinetic parameters:
half-life 3rd:

Any other information on results incl. tables

The intraperitoneal injection of an unknown concentration of
sodium [14C] bicarbonate into CFW mice was followed by
assays (after 24 and 48 hrs and 1, 2, 4 and 12 weeks) of
blood, spleen, liver, kidneys, lungs, brain, jejenum,
muscle, skin, hair and long bones. More than 90% of the
total radioactivity injected was lost via the respiratory
route in one hour. At 24 hrs, most of the radioactivity in
the blood was in noncarbonate form. Specific activity in
long bones parallelled that in the blood for up to 12 weeks.
The radioactivity of the compound injected into a pregnant
mouse was fixed in the foetal tisssues more rapidly than in
the maternal tissues.
Variable and transient responses in erythrocyte counts and
hemoglobin levels in mice to orally administered sodium
bicarbonate was reported.

Applicant's summary and conclusion