Registration Dossier

Administrative data

Description of key information

Potassium silicate can be irritating to corrosive to the skin of rabbits, depending on the molar ratio and concentration.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records

Referenceopen allclose all

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study, but no information on purity of test substance.
Qualifier:
according to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes
Remarks:
Pharmatox Beratung und Forschung GmbH
Species:
rabbit
Strain:
New Zealand White
Details on test animals and environmental conditions:
TEST ANIMALS:
- Weight at study initiation: 3.2 kg (average)
Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
other: deionised water
Controls:
yes, concurrent no treatment
Amount / concentration applied:
Concentration: 7 T49-004:wt%; 0.5 mL
Duration of treatment / exposure:
4 hour(s)
Observation period:
7 days
Number of animals:
5
Details on study design:
- Removal of test substance: yes
- Scoring system: according to Draize
- Examination time points: 1, 24, 48, 72 hours and 7 days
Irritation parameter:
primary dermal irritation index (PDII)
Score:
0

AVERAGE SCORE:
- Erythema: 0
- Edema: 0

No further details on "results" available.


Interpretation of results:
not irritating
Remarks:
Migrated information
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study, but no information on purity of test substance.
Qualifier:
according to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes
Remarks:
Pharmatox Beratung und Forschung GmbH
Species:
rabbit
Strain:
New Zealand White
Details on test animals and environmental conditions:
TEST ANIMALS: 
- Weight at study initiation: 3.2 kg (average) 
Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
other: deionised water
Controls:
yes, concurrent no treatment
Amount / concentration applied:
Concentration: 29 T49-004:wt%; 0.5 mL
Duration of treatment / exposure:
4 hour(s)
Observation period:
7 days
Number of animals:
5
Details on study design:
- Removal of test substance: yes  
- Scoring system: Primary irritation indices from 1 to 4; sum of intact and abraded scores reported
- Examination time points: 1, 24, 48 and 72 hours
Irritation parameter:
primary dermal irritation index (PDII)
Score:
0.25
Reversibility:
fully reversible

AVERAGE SCORE:
- Erythema: 0.25
- Edema: 0
REVERSIBILITY:

24 hours after treatment no effects were observed.

Interpretation of results:
not irritating
Remarks:
Migrated information
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study according to OECD Guideline, but only 1 animal tested. No information on purity of test substance.
Qualifier:
according to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
yes
Remarks:
only one animal tested
GLP compliance:
yes
Remarks:
Inveresk Research International
Species:
rabbit
Strain:
New Zealand White
Details on test animals and environmental conditions:
TEST ANIMALS: 
- Sex: female 
- Source: Cheshire Rabbit Farms Ltd.
- Age: approx. 11 weeks
- Weight at study initiation: 2.3 - 3.0 kg 
Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
water
Controls:
not specified
Amount / concentration applied:
Concentration: 36 T49-004:wt%; 0.5 mL
Duration of treatment / exposure:
4 hour(s)
Observation period:
5 days
Number of animals:
1
Details on study design:
- Removal of test substance: yes (washed away with water)
- Scoring system: according to Draize
- Examination time points: 1, 24, 48, 72 hours and 5 days
Irritation parameter:
primary dermal irritation index (PDII)
Time point:
other: 1, 24, 48, 72 hours and 5 days
Score:
1
Reversibility:
other: Test sample only elicited transient erythema which was clear by day 5.

AVERAGE SCORE:
- Erythema: 1
- Edema: 0

No further details on "results" available.


Interpretation of results:
slightly irritating
Remarks:
Migrated information
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study according to OECD Guideline, but only 1 animal tested.
Qualifier:
according to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
yes
Remarks:
only one animal tested
GLP compliance:
yes
Remarks:
Inveresk Research International
Species:
rabbit
Strain:
New Zealand White
Details on test animals and environmental conditions:
TEST ANIMALS: 
- Strain: New Zealand White
- Sex: male 
- Source: Cheshire Rabbit Farms Ltd.
- Age: approx. 11 weeks
- Weight at study initiation: 2.3 - 3.0 kg 
Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
water
Controls:
not required
Amount / concentration applied:
Concentration: 33 T49-004:wt%; 0.5 mL
Duration of treatment / exposure:
4 hour(s)
Observation period:
5 days
Number of animals:
1
Details on study design:
- Removal of test substance: yes (washed away with water)
- Scoring system: according to Draize
- Examination time points: 1, 24, 48, 72 hours and 5 days
Irritation parameter:
primary dermal irritation index (PDII)
Time point:
other: 1, 24, 48, 72 hours and 5 days
Score:
3
Reversibility:
other: The observed effects (well-defined erythema and very slight oedema) persisted for at least 5 days, the period of observation.

AVERAGE SCORE:
- Erythema: 2
- Edema: 1

No further details on "results" available.

Interpretation of results:
moderately irritating
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study, but no information on purity of test substance.
Qualifier:
according to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes
Remarks:
Pharmatox Beratung und Forschung GmbH
Species:
rabbit
Strain:
New Zealand White
Details on test animals and environmental conditions:
TEST ANIMALS:
- Weight at study initiation: 3.0 kg (average)
Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
other: deionised water
Controls:
yes, concurrent no treatment
Amount / concentration applied:
Concentration: 35 T49-004:wt%; 0.5 mL
Duration of treatment / exposure:
4 hour(s)
Observation period:
7 days
Number of animals:
3
Details on study design:
- Removal of test substance: yes
- Scoring system: according to Draize
- Examination time points: 1, 24, 48, 72 hours and 7 days
Irritation parameter:
primary dermal irritation index (PDII)
Time point:
other: 1, 24, 48, 72 hours and 7 days
Score:
0.17
Reversibility:
other: 48 hours after treatment no effects were observed anymore.
Other effects:
Slight erythema after 1 hour, neglible erythema after 48 hours.

AVERAGE SCORE:
- Erythema: 0.17
- Edema: 0

No further details on "results" available.


Interpretation of results:
not irritating
Remarks:
Migrated information
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study, but no information on purity of test substance.
Qualifier:
according to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes
Remarks:
Pharmatox Beratung und Forschung GmbH
Species:
rabbit
Strain:
New Zealand White
Details on test animals and environmental conditions:
TEST ANIMALS: 
- Weight at study initiation: 3.0 kg (average)
Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
other: deionised water
Controls:
yes, concurrent no treatment
Amount / concentration applied:
Concentration: 8.8 T49-004:wt%; 0.5 mL
Duration of treatment / exposure:
4 hour(s)
Observation period:
7 days
Number of animals:
3
Details on study design:
- Removal of test substance: yes
- Scoring system: according to Draize
- Examination time points: 1, 24, 48, 72 hours and 7 days
Irritation parameter:
primary dermal irritation index (PDII)
Time point:
other: 1, 24, 48, 72 hours and 7 days
Score:
0
Reversibility:
fully reversible
Other effects:
Very slight erythema was observed 24 and 48 hours after treatment. None of these effects were observed thereafter. This is reported in the summary but not in the table of effects.

AVERAGE SCORE:
- Erythema: 0
- Edema: 0
REVERSIBILITY:

48 hours after treatment the effects were no longer present.

No further details on "results" available.


Interpretation of results:
not irritating
Remarks:
Migrated information
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
18 Oct 2004 - 16 Dec 2004
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets national standard methods with acceptable restrictions; GLP
Qualifier:
according to
Guideline:
EPA OPPTS 870.2500 (Acute Dermal Irritation)
Deviations:
no
GLP compliance:
yes
Remarks:
Product Safety Laboratories
Species:
rabbit
Strain:
New Zealand White
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: Robinson Services Inc.
- Age at study initiation: young adult
- Housing: singly in stainless steel cages
- Diet (e.g. ad libitum): pelleted Purina Rabbit Chow #5326
- Water (e.g. ad libitum): filtered tap water
- Acclimation period: 7 or 13 days


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 - 22
- Photoperiod (hrs dark / hrs light): 12/12


IN-LIFE DATES: From: 3 Nov To: 12 Nov 2004
Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL
- Concentration (if solution): assumed to be 30%
Duration of treatment / exposure:
4 h
Observation period:
1, 24, 48 and 72 h after removal of test substance
Number of animals:
3
Details on study design:
TEST SITE
- Area of exposure: 6 cm2 on the dorsal area and the trunk
- Type of wrap if used: 4-ply gauze pad wrapped with Micropore tape


REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 3 min, 1 and 4 h after application


SCORING SYSTEM:
Evaluation for corrosion (PDII) and according to Draize et al., 1944 (data not presented)
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Score:
0.4
Reversibility:
fully reversible within: 72 h

All animals did not show signs of systemic toxicity. Very slight erythema was observed one hour after removal of the test patch in 3/3 animals. Within 72 h all animals were free of dermal irritation.

Interpretation of results:
slightly irritating
Remarks:
Migrated information
Endpoint:
skin irritation / corrosion, other
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature available (review).
Principles of method if other than guideline:
Method: other: FHSA test specified in 16 C.F.R. 1500.41 et.seq.
GLP compliance:
no
Species:
rabbit
Type of coverage:
occlusive
Amount / concentration applied:
Concentration: 29 other: wt%
Duration of treatment / exposure:
24 hour(s)
Irritation parameter:
primary dermal irritation index (PDII)
Score:
0

RS-Freetext:
AVERAGE SCORE: Not reported
REVERSIBILITY: Not reported
OTHER EFFECTS: Not reported

Interpretation of results:
not irritating
Remarks:
Migrated information
Endpoint:
skin irritation / corrosion, other
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature available (review).
Principles of method if other than guideline:
Method: other: FHSA test specified in 16 C.F.R. 1500.41 et.seq.
GLP compliance:
no
Species:
rabbit
Type of coverage:
occlusive
Amount / concentration applied:
Concentration: 39 other: wt%
Duration of treatment / exposure:
24 hour(s)
Irritation parameter:
primary dermal irritation index (PDII)
Score:
2

RS-Freetext:
AVERAGE SCORE: Not reported
REVERSIBILITY: Not reported
OTHER EFFECTS: Not reported

Interpretation of results:
slightly irritating
Remarks:
Migrated information
Endpoint:
skin irritation / corrosion, other
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature available (review).
Principles of method if other than guideline:
Method: other: FHSA test specified in 16 C.F.R. 1500.41 et.seq.
GLP compliance:
no
Species:
rabbit
Type of coverage:
occlusive
Amount / concentration applied:
Concentration: 85 other: wt%
Duration of treatment / exposure:
24 hour(s)
Irritation parameter:
primary dermal irritation index (PDII)
Score:
8

RS-Freetext:
AVERAGE SCORE: Not reported
REVERSIBILITY: Not reported
OTHER EFFECTS: Not reported

Interpretation of results:
highly irritating
Remarks:
Migrated information

Eye irritation

Link to relevant study records

Referenceopen allclose all

Endpoint:
eye irritation, other
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature available (review).
Principles of method if other than guideline:
Method: other: FHSA Draize method specified in 16 C.F.R. 1500.42
GLP compliance:
no
Species:
rabbit
Amount / concentration applied:
Concentration: 80 other: wt%
Reversibility:
not specified
Remarks on result:
other: highly irritating

RS-Freetext:
AVERAGE SCORE: Not reported
DESCRIPTION OF LESIONS: Not reported
REVERSIBILITY: Not reported
OTHER EFFECTS: Not reported

Interpretation of results:
highly irritating
Remarks:
Migrated information
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study, but no information on purity of test substance.
Qualifier:
according to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
yes
Remarks:
Pharmatox Beratung und Forschung GmbH
Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 3.0 - 3.2 kg 
Vehicle:
water
Controls:
not required
Amount / concentration applied:
Concentration: 29 T49-004:wt%
Amount applied: 0.1 ml
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
6
Details on study design:
Comment: not rinsed
- Postexposure period: scoring done at 1, 2, 4, 8 hours and 1-7 days daily 
- Ophtalmoscopic examination: cornea, iris, conjunctiva
- Scoring system: according to OECD Guideline 405
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 1, 2, 4, 8 hours and 1-7 days daily 
Score:
0
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 1, 2, 4, 8 hours and 1-7 days daily 
Score:
0
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 1, 2, 4, 8 hours and 1-7 days daily 
Score:
1.5
Reversibility:
fully reversible within: 2 days
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 1, 2, 4, 8 hours and 1-7 days daily 
Score:
0.7
Reversibility:
fully reversible within: 2 days

No further details on "results" available.

Interpretation of results:
not irritating
Remarks:
Migrated information
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study, but no information on purity of test substance.
Qualifier:
according to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
yes
Remarks:
Pharmatox Beratung und Forschung GmbH
Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
TEST ANIMALS:
- Weight at study initiation: 3.0 -3.2 kg
Vehicle:
other: deionised water
Controls:
yes, concurrent no treatment
Amount / concentration applied:
Concentration: 7 T49-004:wt%
Amount applied: 0.1 ml
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
6
Details on study design:
Comment: not rinsed
- Post-exposure period scoring at: 1, 2, 4, 8 hours and day 1-7 daily 
- Ophtalmoscopic examination: cornea, iris, conjunctivae
- Scoring system: according to OECD Guideline 405'
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 1, 2, 4, 8 hours and day 1-7 daily 
Score:
0
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 1, 2, 4, 8 hours and day 1-7 daily 
Score:
0
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 1, 2, 4, 8 hours and day 1-7 daily 
Score:
0.7
Reversibility:
fully reversible within: 2 days
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 1, 2, 4, 8 hours and day 1-7 daily 
Score:
0

No further details on "results" available.

Interpretation of results:
not irritating
Remarks:
Migrated information
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study, but no information on purity of test substance.
Qualifier:
according to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
yes
Remarks:
Pharmatox Beratung und Forschung GmbH
Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
TEST ANIMALS 
- Weight at study initiation: 3.0 -3.2 kg 
Vehicle:
water
Controls:
yes, concurrent no treatment
Amount / concentration applied:
Concentration: 35 T49-004:wt%
Amount applied: 0.1 ml
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
3
Details on study design:
Comment: not rinsed
- Postexposure period: scoring done at 1, 2, 4, 8 hours and 1-7 days daily 
- Ophtalmoscopic examination: cornea, iris, conjuntiva 
- Scoring system: according to OECD Guideline 405
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 1, 2, 4, 8 hours and 1-7 days daily 
Score:
0
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 1, 2, 4, 8 hours and 1-7 days daily 
Score:
0
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 1, 2, 4, 8 hours and 1-7 days daily 
Score:
1.2
Reversibility:
not reversible
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 1, 2, 4, 8 hours and 1-7 days daily 
Score:
1.4
Reversibility:
not reversible

AVERAGE SCORE:
- Cornea: 0/0/0 
- Iris: 0/0/0
- Conjunctivae (redness): 1.0/1.3/1.3
- Conjunctivae (chemosis): 1.5/1.3/1.5


REVERSIBILITY:

The effects observed persisted for at least 6
to 7 days after treatment (period of observation).

Interpretation of results:
slightly irritating
Remarks:
Migrated information
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study, but no information on purity of test substance.
Qualifier:
according to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
yes
Remarks:
Pharmatox Beratung und Forschung GmbH
Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 3.0 - 3.2 kg 
Vehicle:
water
Controls:
yes, concurrent no treatment
Amount / concentration applied:
Concentration: 8.8 T49-004:wt%
Amount applied: 0.1 ml
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
3
Details on study design:
Comment: not rinsed
- Postexposure period: scoring done at 1, 2, 4, 8 hours and 1-7 days daily
- Ophtalmoscopic examination: cornea, iris, conjunctiva 
- Scoring system: according to OECD Guideline 405
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 1, 2, 4, 8 hours and 1-7 days daily 
Score:
0
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 1, 2, 4, 8 hours and 1-7 days daily 
Score:
0
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 1, 2, 4, 8 hours and 1-7 days daily 
Score:
0.7
Reversibility:
fully reversible within: 2 days
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 1, 2, 4, 8 hours and 1-7 days daily 
Score:
0

No further details on "results" available.

Interpretation of results:
not irritating
Remarks:
Migrated information
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets national standard methods with acceptable restrictions; GLP
Qualifier:
according to
Guideline:
EPA OPPTS 870.2400 (Acute Eye Irritation)
Deviations:
no
GLP compliance:
yes
Remarks:
Product Safety Laboratories
Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
TEST ANIMALS
- Source: Robinson Services Inc.
- Age at study initiation: young adult
- Housing: singly in stainless steel cages
- Diet (e.g. ad libitum): pelleted Purina Rabbit Chow #5326
- Water (e.g. ad libitum): filtered tap water
- Acclimation period: 7 days


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 23
- Photoperiod (hrs dark / hrs light): 12/12


IN-LIFE DATES: From: 10 Nov To: 17 Nov 2004
Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL
- Concentration (if solution): assumed to be 30%
Duration of treatment / exposure:
The test substance remained in the eye.
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
3
Details on study design:
SCORING SYSTEM:
According to Draize et al. 1944


TOOL USED TO ASSESS SCORE: high-intenstity white light and fluorescein dye evaluation after 24 h
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 1 h
Score:
0
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 1 h
Score:
0
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 1 h
Score:
2
Reversibility:
fully reversible within: 7 days
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24 h
Score:
1.7
Reversibility:
fully reversible within: 7 days
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 48 h
Score:
1.3
Reversibility:
fully reversible within: 7 days
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 72 h
Score:
1.3
Reversibility:
fully reversible within: 7 days
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 1 h
Score:
2
Reversibility:
fully reversible within: 4 days
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 24 h
Score:
1.7
Reversibility:
fully reversible within: 4 days
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 48 h
Score:
1
Reversibility:
fully reversible within: 4 days
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 72 h
Score:
0.3
Reversibility:
fully reversible within: 4 days
Interpretation of results:
slightly irritating
Remarks:
Migrated information

Additional information

As observed with sodium silicates, potassium silicates of comparable concentrations and different molar ratios show an inverse correlation to irritancy. Molar ratios of 2.0 - 3.0 and 30 - 36% were irritating to the skin, whereas molar ratios of 3.4 and 3.9 (29- 35%) caused no irritation.

At concentrations up to 35% potassium silicates with molar ratio of 2.47, 3.4 and 3.9 were only slightly or not irritating to the eyes of rabbits.

Justification for classification or non-classification

DSD: Irritating to corrosive depending on the molar ratio/specific concentration limit.

CLP: