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EC number: 215-199-1 | CAS number: 1312-76-1
No clearly treatment related effects at tested dose levels of 200, 600 and 1800 ppm (corresponding to 26.4, 76.2 and 227.1 mg/kg/day, respectively, for males; and 32.1, 97.6 and 237.2 mg/kg/day, respectively, for females).
TOXIC RESPONSE/EFFECTS BY DOSE LEVEL: - Mortality and time to death: None - Clinical signs: No effects - Body weight gain: No effects - Food/water consumption: No effects - Clinical chemistry: No effects - Haematology: No effects - Urinalysis: No effects - Organ weights: No effects - Gross pathology: No effects - Histopathology: Except for the kidneys, no morphological changes have been observed in the organs examined. The observed
histological changes in the kidneys (tubule wall calcinosis, glomerular swelling, tubule swelling, weakening of the renal tubule cell
walls and dilation of the tubule lumen) were not dose-related and occurred also in the controls. Cylindrical inclusions in the renal
tubular cells were only observed in the medium dosage group.
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