Registration Dossier
Registration Dossier
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EC number: 229-912-9 | CAS number: 6834-92-0
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Safety of the metal scavengers sodium metasilicate and sodium polyphosphate.
- Author:
- Saiwai K et al.
- Year:
- 1 980
- Bibliographic source:
- Internal Report Toho University
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
- Principles of method if other than guideline:
- Type: other: male and female reproduction organs
- GLP compliance:
- no
- Type of method:
- in vivo
Test material
- Reference substance name:
- Disodium metasilicate
- EC Number:
- 229-912-9
- EC Name:
- Disodium metasilicate
- Cas Number:
- 6834-92-0
- Molecular formula:
- H2O3Si.2Na Soluble Silicates Category
- IUPAC Name:
- disodium oxosilanediolate
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: ddy-SLC
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- water
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 3 months
- Frequency of treatment:
- ad libitum
- Duration of test:
- 3 months
Doses / concentrations
- Remarks:
- Doses / Concentrations:
300, 900, 2700 ppm (males), 333, 1000, 3000 ppm (females)
Basis:
- Control animals:
- yes, concurrent vehicle
Results and discussion
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- > 2 700 ppm
- Sex:
- male
- Dose descriptor:
- NOAEL
- Effect level:
- > 3 000 ppm
- Sex:
- female
Any other information on results incl. tables
No effects on reproductive organs upon microscopic examination and wet weight determination.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
