Registration Dossier
Registration Dossier
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EC number: - | CAS number: 2156592-70-8
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- other: Experimental study with similar substance
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: We do not have the complete test report but only an extract given in the OECD SIDS report : Benzene C10-16 alkyl derivatives
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 475 (Mammalian Bone Marrow Chromosome Aberration Test)
- Principles of method if other than guideline:
- Method EPA/TSCA bone marrow chromosome abberation
- GLP compliance:
- yes
- Type of assay:
- chromosome aberration assay
Test material
- Reference substance name:
- Alkylate 225
- IUPAC Name:
- Alkylate 225
- Details on test material:
- Alkylate is a linear alkyl benzene with an alkyl substituent including < 1% C9, 7% C10, 25% C11, 48 % C12, 19% C13, 1% C14
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- no data
- Details on exposure:
- no data
- Positive control(s):
- no data
Examinations
- Details of tissue and slide preparation:
- no data
Results and discussion
Test results
- Sex:
- not specified
- Genotoxicity:
- negative
- Toxicity:
- yes
- Remarks:
- lowest producing toxicity : 127000 mg/kg
- Additional information on results:
- Effect on Mitotic index or P/N Ratio : no effect
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: negative
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