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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
other: Expert judgement
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Product brochure of producers association; data without proof.
Principles of method if other than guideline:
Expert judgement based on structural considerations.

RM-Freetext:
Soluble silicates have no bioaccumulation potential. There are no  structural alerts to suspect such a hazard.

Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well documented publications giving sufficient detail for evaluation.
Principles of method if other than guideline:
Feeding studies with rats, dogs, cats and guinea pigs. Measurement of urinary excretion by silica analysis of urine samples.
GLP compliance:
no
Test organisms (species):
other: rats, dogs, cats and guinea pigs
Route of exposure:
feed
Remarks on result:
not measured/tested
Remarks:
See "Any other information on results incl. tables"

Ingested silicates are excreted via urine and to a lesser extent via the  faeces. Markedly increased and rapid urinary excretion of 

silicawas  observed when soluble sodium silicates were administered to rats (Benke &  Osborn, 1979), dogs (King et al., 1933),

cats (King & McGeorge, 1938) and  guinea pigs (Sauer et al., 1959). The urinary silicon excretion half-life  after administration of

sodium silicate to rats via stomach tube was 24 h  (Benke & Osborn, 1979).

Based on these metabolic considerations no bioaccumulation is to be  expected.

Description of key information

Low potential for bioaccumulation.

Key value for chemical safety assessment

Additional information

Toxicokinetic data on vertebrates revealed a low potential for bioaccumulation. Ingested soluble silicates are excreted via urine and to a lesser extent via the faeces. Markedly increased and rapid urinary excretion of silica was observed when soluble sodium silicates were administered to rats (Benke & Osborn 1979), dogs (King et al. 1933), cats (King & McGeorge 1938) and guinea pigs (Sauer et al. 1959). The urinary silicon excretion half-life after administration of sodium silicate to rats via stomach tube was 24 h (Benke & Osborn 1979).