Registration Dossier

Toxicological information

Health surveillance data

Currently viewing:

Administrative data

Endpoint:
health surveillance data
Type of information:
other: case report
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Ulcerative contact dermatitis caused by sodium silicate. Coexistence of primary irritant contact dermatitis and contact urticaria.
Author:
Tanaka T et al.
Year:
1982
Bibliographic source:
Arch. Dermatol. 118, 518-520
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2004
Report Date:
2004

Materials and methods

Study type:
human medical data
Endpoint addressed:
skin sensitisation
Principles of method if other than guideline:
Case study observations
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
20 % sodium silicate solution of unknown molar ratio.

Method

Type of population:
occupational
Ethical approval:
not applicable

Results and discussion

Results:
A fifty-seven year old dyer was regularly exposed at work to 20 % sodiumsilicate solution of unknown molar ratio. The man had recurrent ulcerative lesions on his left hand over a period of two years. The  ulcers were associated with chronic eczematous changes resulting from  primary irritant contact dermatitis to sodium silicate, as indicated by a positive patch test. The man also had another type of cutaneous reaction  to sodium silicate, contact urticaria. An immediate wheal and flare  reaction was seen fifteen minutes after the application of sodium  silicate to a scratch test site. Such a response was not seen in healthy  control subjects.

Applicant's summary and conclusion