Registration Dossier
Registration Dossier
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EC number: 215-687-4 | CAS number: 1344-09-8
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: Case study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Health, safety and environmental aspects of soluble silicates.
- Author:
- Schleyer WL and Blumberg JG (1982).
- Year:
- 1 982
- Bibliographic source:
- In Soluble Silicates, Falcone JS (ed). ACS Symposium Series 194, Chapter 4, 49-69.
- Reference Type:
- publication
- Title:
- Tod durch perorale Aufnahme von Wasserglas (Natriumsilikat).
- Author:
- Sigrist Th and Flury K
- Year:
- 1 985
- Bibliographic source:
- Z. Rechtsmed. 94, 245-250.
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- acute toxicity: oral
- Principles of method if other than guideline:
- Case study
- GLP compliance:
- no
Test material
- Reference substance name:
- Silicic acid, sodium salt
- EC Number:
- 215-687-4
- EC Name:
- Silicic acid, sodium salt
- Cas Number:
- 1344-09-8
- Molecular formula:
- Na2O x (SiO2)n with Molar Ratio (MR) (SiO2/Na2O): 1.5 – 4
- IUPAC Name:
- sodium hydroxy(oxo)silanolate
- Details on test material:
- Although the authors state that sodium metasilicate was used (in form of an egg preserving solution from a local drug store), the relatively low pH of 12.5 makes it more likely that a silicate solution of a molar ratio of greater than 1.0 was ingested. Moreover, egg preservatives typically contain 5-36% of 3.2 SiO2/Na2O silicate (Schleyer & Blumberg, 1982).
Constituent 1
Method
- Type of population:
- general
- Subjects:
- 68-year old women
- Ethical approval:
- not applicable
- Route of exposure:
- oral
- Reason of exposure:
- intentional
- Exposure assessment:
- not specified
- Details on exposure:
- Ingestion of 500 ml of an egg-preserving solution.
Results and discussion
- Clinical signs:
- Ingestion of 500 ml of an egg-preserving solution containing sodium silicate in suicidal intention led to death of a 68 year old woman within 1 hour by suffocation. Aspiration of the vomited silicate solution caused obstruction of the lungs by precipitation of amorphous silica. The transformation of sodium silicate from liquid to solid occured in the lungs by means of the carbonic acid of expiration air.
Applicant's summary and conclusion
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