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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: Case study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Health, safety and environmental aspects of soluble silicates.
Author:
Schleyer WL and Blumberg JG (1982).
Year:
1982
Bibliographic source:
In Soluble Silicates, Falcone JS (ed). ACS Symposium Series 194, Chapter 4, 49-69.
Reference Type:
publication
Title:
Tod durch perorale Aufnahme von Wasserglas (Natriumsilikat).
Author:
Sigrist Th and Flury K
Year:
1985
Bibliographic source:
Z. Rechtsmed. 94, 245-250.
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2004
Report Date:
2004

Materials and methods

Study type:
poisoning incident
Endpoint addressed:
acute toxicity: oral
Principles of method if other than guideline:
Case study
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Although the authors state that sodium metasilicate was used (in form of an egg preserving solution from a local drug store), the relatively low pH of 12.5 makes it more likely that a silicate solution of a molar ratio of greater than 1.0 was ingested. Moreover, egg preservatives typically contain 5-36% of 3.2 SiO2/Na2O silicate (Schleyer & Blumberg, 1982).

Method

Type of population:
general
Subjects:
68-year old women
Ethical approval:
not applicable
Route of exposure:
oral
Reason of exposure:
intentional
Exposure assessment:
not specified
Details on exposure:
Ingestion of 500 ml of an egg-preserving solution.

Results and discussion

Clinical signs:
Ingestion of 500 ml of an egg-preserving solution containing sodium  silicate in suicidal intention led to death of a 68 year old woman within 1 hour by suffocation. Aspiration of the vomited silicate solution caused obstruction of the lungs by precipitation of amorphous silica. The transformation of sodium silicate from liquid to solid occured in the lungs by means of the carbonic acid of expiration air.

Applicant's summary and conclusion