Registration Dossier

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
other: General considerations
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature (review).

Data source

Referenceopen allclose all

Title:
No information
Author:
Schleyer WL and Blumberg JG (1982). Health, safety and|environmental aspects of soluble silicates. In Soluble|Silicates, Falcone JS (ed). ACS Symposium Series 194,|Chapter 4, 49-69.
Title:
No information
Author:
Select Committee on GRAS Substances, Evaluation of the Health Aspects of Certain Silicates as Food Ingredients, SCOGS-61, Federation of American Societies for Experimental Biology, NTIS Publication 301-402/AS, Springfield, Va., p.4, 1979.

Materials and methods

Type of study / information:
Type of experience: other
Principles of method if other than guideline:
General scientific considerations.

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
TS-Freetext:
Sodium silicate, no further information on molar ratio and
concentration given.

Results and discussion

Any other information on results incl. tables

RM-Freetext:
In man, the lethal oral dose of sodium silicates has been
estimated as 0.5-5 g/kg, depending on the molar ratio.

In the USA sodium silicate is considered "generally
recognized as safe (GRAS)" for indirect food uses, and as
additive to drinking water in concentrations of up to 100
ppm.

Applicant's summary and conclusion