2,4,6-trinitrotoluene

Toxicity to birds

Link to relevant study record(s)

Reference

Endpoint:

long-term toxicity to birds

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Principles of method if other than guideline:

90-d toxicity on birds, sub-chronic dietary exposure.

GLP compliance:

not specified

Dose method:

feed

Analytical monitoring:

yes

Vehicle:

no

Test organisms (species):

Colinus virginianus

Total exposure duration (if not single dose):

90 d

No. of animals per sex per dose and/or stage:

5

Control animals:

yes, plain diet

Duration (if not single dose):

90 d

Dose descriptor:

other: LOAEL

Effect level:

ca. 178 mg/kg bw/day

Conc. / dose based on:

test mat.

Basis for effect:

mortality

Duration (if not single dose):

90 d

Dose descriptor:

other: NOAEL

Effect level:

>= 7 mg/kg bw/day

Conc. / dose based on:

test mat.

Basis for effect:

mortality

Description of key information

Based on the results of this 90-d study, a low observedadverse- effect level in the serious category (i.e., due to the incidence of mortality) was determined to be 178 mg/kg/d. Acknowledging the limitations of this study, we estimated a no-observable-adverse-effect level (NOAEL) of 7 mg/kg/d. We wish to point out that this NOAEL may be an underestimation of the true NOAEL and that other target tissues (e.g., CNS) will need to be investigated to increase confidence in the present estimated NOAEL in TNT-exposed birds

Key value for chemical safety assessment

Long-term EC10, LC10 or NOEC for birds:

7 mg/kg food