Registration Dossier
Registration Dossier
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EC number: 203-551-7 | CAS number: 108-11-2
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 359 mg/L
Additional information
An acute study was conducted to assess the acute toxicity of MIBC in Rainbow Trout. The study followed GLP and was rated ‘1’ for reliability under Klimisch standards. Furthermore, the guidelines set forth in OECD Guideline 203, EPA OTS 797.1400, and EU Method C.1 were followed without deviation. The 24-, 48-, 72 -, and 96 -hour LC50 values were each 359 mg/L, and the 96 -hour NOEC was 105 mg/L and was determined based on biological interpretation of the data and the highest exposure level exhibiting no fish mortality or sublethal effects.
Another acute toxicity study was performed to assess the acute toxicity of MIBC to the freshwater fish species Pimephales promelas (Daly, 1999). The study was conducted according to OECD Guideline 203 with no exceptions, as well as EU Method C.1 with no exceptions. The 96-hour LC50 for MIBC was reported to be greater than 92.4 mg/L.
One 24-hour toxicity study was conducted in Carassius auratus (Bridié et al., 1973). The examiners followed OECD guideline 203; however, significant deviations were noted. These deviations included purity of the test substance, time-points of observations, negative controls, and the methodology for determination of mortality not provided, as well as a lack of statistical methods, and the test duration being 24 hours. The loading of fish rate was 1.3 g fish per litre of water. The medium tolerance limit (TLm) (the concentration at which 50% animals survive) at 24 hours was reported to be 360 mg/L in C. auratus.
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