Registration Dossier
Registration Dossier
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EC number: 200-574-4 | CAS number: 64-04-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
Test material
- Reference substance name:
- Phenethylamine
- EC Number:
- 200-574-4
- EC Name:
- Phenethylamine
- Cas Number:
- 64-04-0
- Molecular formula:
- C8H11N
- IUPAC Name:
- 2-phenylethanamine
- Test material form:
- liquid
- Details on test material:
- Name of the test substance used in the study report: 2-Phenylethylamin
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye of the same animal
- Amount / concentration applied:
- 0.05 ml
- Duration of treatment / exposure:
- 1 h
- Observation period (in vivo):
- 8 d
- Number of animals or in vitro replicates:
- 2
Results and discussion
In vivo
Results
- Irritation parameter:
- other:
- Time point:
- 24/48/72 h
- Reversibility:
- not reversible
- Remarks on result:
- not determinable
- Remarks:
- after application of the test substance, the whole eyes were destroyed (development of a staphyloma)
- Irritant / corrosive response data:
- Already after 1 hour, the eyes were corroded.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
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