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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
The study was conducted in 1975.
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Abstract only.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The test substance was administered orally to rats at a range of concentrations and the rats were observed for fourteen days.
GLP compliance:
no
Remarks:
Study pre-dates GLP.
Test type:
other: No data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
6-isopropyl-3-methylcyclohex-2-enone
EC Number:
201-942-7
EC Name:
6-isopropyl-3-methylcyclohex-2-enone
Cas Number:
89-81-6
Molecular formula:
C10H16O
IUPAC Name:
6-isopropyl-3-methylcyclohex-2-enone
Test material form:
not specified
Details on test material:
Name: Piperitone

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
The test substance was administered orally to rats at a range of concentrations and the rats were observed for fourteen days.
Doses:
1.31, 2.56, 5.0 and 9.75 g/kg.
No. of animals per sex per dose:
10 animals per dose, sex not specified.
Control animals:
no
Details on study design:
The test substance was administered orally to rats at a range of concentrations and the rats were observed for fourteen days.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 550 mg/kg bw
Based on:
test mat.
95% CL:
2 450 - 4 650
Mortality:
Mortality occurred at 2.56, 5.0 and 9.75 g/kg.
Clinical signs:
other: At 1.31 g / kg and 2.56 g / kg slight lethargy was observed. At 5.0 g/kg lethargy and piloerection were observed. At 9.75 g/kg coma was observed.

Any other information on results incl. tables

Summary of mortality

Dose

g/kg

Death / No. of animals

Observation day

1

2

3

4

5

6

7

8

9

10

11

12

13

14

1.31

0 / 10

0

0

0

0

0

0

0

0

0

0

0

0

0

0

2.56

2 / 10

0

0

1

0

0

0

0

1

0

0

0

0

0

0

5.0

8 / 10

7

1

0

0

0

0

0

0

0

0

0

0

0

0

9.75

10 / 10

9

1

0

0

0

0

0

0

0

0

0

0

0

0

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute oral LD50 was 3.55 g/kg with 95 % confidence limits of 2.45 – 4.65 g/kg.
Executive summary:

The acute oral toxicity of the test substance was assessed. The acute oral LD50 was 3.55 g/kg with 95 % confidence limits of 2.45 – 4.65 g/kg. Therefore no classification is required.