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Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Referenceopen allclose all

Reference Type:
other: Predicted data
Title:
No information
Author:
Gedeon Richter Plc. Health and Safety Department
Year:
2015
Bibliographic source:
QSAR Toolbox 3.1.0.21
Reference Type:
other: Predicted data
Title:
No information
Author:
Gedeon Richter Plc. Health and Safety Department
Year:
2015
Bibliographic source:
T.E.S.T. version 4.1

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: REACH guidance on QSARs R.6, May/July2008

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methylcyclopentane-1,3-dione
EC Number:
212-153-2
EC Name:
2-methylcyclopentane-1,3-dione
Cas Number:
765-69-5
Molecular formula:
C6H8O2
IUPAC Name:
2-methylcyclopentane-1,3-dione

Results and discussion

Effect concentrations
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
723.155
Nominal / measured:
estimated
Remarks on result:
not measured/tested

Any other information on results incl. tables

Sublethal observations / clinical signs:

Software Database / Method Endpoint Test duration Species Predicted value (mg/L)
QSAR Toolbox Aquatic OASIS LC50 96 h Pimephales promales 426
T.E.S.T. Consensus method LC50 96 h Fathead minnow 466,46
T.E.S.T. Hiearchical Clustering Method LC50 96 h Fathead minnow 1045,86
T.E.S.T. Single Model Method LC50 96 h Fathead minnow 923,29
T.E.S.T. Group Contribution Method LC50 96 h Fathead minnow 515,5
T.E.S.T. Nearest neighbor method LC50 96 h Fathead minnow 961,82
Inferential result 723,155 mg/L

Applicant's summary and conclusion

Conclusions:
According to (Q)SAR modells: QSAR Toolbox, T.E.S.T. the predicted values indicated that methyl-ciklopentanedione is not hazardous to fishes. The result does not meet the requirement of any Aquatic Acute Category.