Registration Dossier
Registration Dossier
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EC number: 205-509-3 | CAS number: 141-91-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication which meets basic scientific principles. Results only as data tables.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 962
Materials and methods
- Principles of method if other than guideline:
- see details in remarks on material and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,6-dimethylmorpholine
- EC Number:
- 205-509-3
- EC Name:
- 2,6-dimethylmorpholine
- Cas Number:
- 141-91-3
- Molecular formula:
- C6H13NO
- IUPAC Name:
- 2,6-dimethylmorpholine
- Details on test material:
- - Name of test material (as cited in study report): 2,6-dimethylmorpholine
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- no data
- Number of animals or in vitro replicates:
- no data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 7
- Max. score:
- 10
- Reversibility:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the highly irritating eye effects observed the test substance has to be classified with "Risk of serious damage to eyes" in accordance with Directive 67/548/EEC (DSD).
- Executive summary:
Eye injury in rabbits is recorded in a 10-grade ordinal series and is based upon the degree of corneal necrosis that results from instillation of various volumes and concentrations of chemical, as detailed by Carpenter and Smyth. Grade 1 in the Table indicates at most a very small area of necrosis resulting from 0.5 ml of undiluted chemical in the eye. Grade 5 indicates a so-called severe burn from 0.005 ml, and Grade 10 indicates a severe burn from 0.5 ml of a 1% solution in water or propylene glycol.
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