Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1995
Report Date:
1995

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: not specified
GLP compliance:
yes
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Physical form of substance: liquid

Test animals

Species:
rat

Administration / exposure

Vehicle:
other: none
Details on inhalation exposure:
4h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
< 1 mg/L air
Exp. duration:
4 h
Mortality:
Male: .19 mg/L; Number of animals: 5; Number of deaths: 0
Male: .61 mg/L; Number of animals: 5; Number of deaths: 0
Male: .82 mg/L; Number of animals: 5; Number of deaths: 0
Male: 1.13 mg/L; Number of animals: 5; Number of deaths: 5
Male: 1.79 mg/L; Number of animals: 5; Number of deaths: 5
Male: 4.8 mg/L; Number of animals: 5; Number of deaths: 5
Female: .19 mg/L; Number of animals: 5; Number of deaths: 0
Female: .61 mg/L; Number of animals: 5; Number of deaths: 0
Female: .82 mg/L; Number of animals: 5; Number of deaths: 0
Female: 1.13 mg/L; Number of animals: 5; Number of deaths: 5
Female: 1.79 mg/L; Number of animals: 5; Number of deaths: 5
Female: 4.8 mg/L; Number of animals: 5; Number of deaths: 5
Clinical signs:
other: During the exposure most of the animals showed signs of an irritation e.g abnorm breating, closing or partial closing of the eyes and abnorm position. Directly after the exposure clinical signs as abnorm breathing, hypersensibility against touching and no
Gross pathology:
Macroscopic pathology: stowed lungs in all died animals. In many animals, which died during the study, the stomach was filled with liquid.
No change were observed in the animals surviving the treatment.

Applicant's summary and conclusion

Interpretation of results:
toxic
Remarks:
Migrated information Criteria used for interpretation of results: EU