Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study performed according to EG B.3 Teil B / OECD 402

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1995
Report Date:
1995

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: EG B.3 Teil B / OECD 402
GLP compliance:
yes
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
other: rat, Sprague-Dawley

Administration / exposure

Type of coverage:
occlusive
Vehicle:
other: none
Details on dermal exposure:
24h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 1260 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 3200 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 1260 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 2
Female: 3200 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Body weight gains were reduced on day 8 in most of the
animals, especially in that which received 2000 or 3200
mg/kg.
Gross pathology:
In the animals which died during the study: unregullar areas of pallor in the liver.
Other findings:
none

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU