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EC number: 234-465-8 | CAS number: 12005-21-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015-08-04 to 2015-08-11
- Reliability:
- 1 (reliable without restriction)
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- yes
- Remarks:
- Study not completed due to insolubility of the tested substance
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Pentaaluminium triyttrium dodecaoxide
- EC Number:
- 234-465-8
- EC Name:
- Pentaaluminium triyttrium dodecaoxide
- Cas Number:
- 12005-21-9
- Molecular formula:
- Al5O12Y3
- IUPAC Name:
- pentaaluminium triyttrium dodecaoxide
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): L181
- Physical state: solid powder
- Analytical purity: > 99 %
- Impurities (identity and concentrations): not applicable
- Composition of test material, percentage of components: almost pure substance
- Lot/batch No.: PK-Nr. 65365, ANS-Nr. PC71 54
- Expiration date of the lot/batch: does not expire
- Stability under test conditions: stable
- Storage condition of test material: room temperature
Constituent 1
Method
- Target gene:
- not applicable as study not completed
- Test concentrations with justification for top dose:
- not applicable as study not completed
- Vehicle / solvent:
- not applicable as study not completed
- Details on test system and experimental conditions:
- not applicable as study not completed
- Evaluation criteria:
- not applicable as study not completed
- Statistics:
- not applicable as study not completed
Results and discussion
Test results
- Species / strain:
- other: not applicable as study not completed
- Metabolic activation:
- not applicable
- Genotoxicity:
- negative
- Remarks:
- The substance is completely insoluble in water, DMSO, ethanol, acetone, tetrahydrofurane or isopropanol. It is not bioavailable for the bacterial cell.
- Cytotoxicity / choice of top concentrations:
- other: not applicable as study not completed
- Vehicle controls validity:
- other: not applicable as study not completed
- Untreated negative controls validity:
- other: not applicable as study not completed
- Positive controls validity:
- other: not applicable as study not completed
- Additional information on results:
- not applicable as study not completed
- Remarks on result:
- other: other: not applicable as study not completed
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
The study was not completed due to the insolubility of the test item.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
The substance is not capable of show ing mutagenic activity in a GLP-guideline study according to OECD 471 (Ames-test). - Executive summary:
The substance is completely insoluble in water, DMSO, ethanol, acetone, tetrahydrofurane or isopropanol. Due the chemical nature of the substance only acid hydrolysis or similar decomposition methods would result in soluble matter.
Testing of the substance as a suspension is not in line with the guideline. Results produced with suspensions are usually not accepted by authorities.
The substance is not bioavailable for the bacterial cell in the Ames test or other in vitro test methods due to its insolubility. The substance is not capable of interfering with the genome in the bacterial cell. Hence, the Ames-test is negative as a basic principle.
The same applies for potential mutagenic activity under natural conditions.
Testing for genetic toxicity in vitro was aimed for but was technically not possible. REACH Annex XI no. 2: "Testing for a specific endpoint may be omitted, if it is technically not possible to conduct the study as a consequence of the properties of the substance..."
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