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EC number: 202-223-0 | CAS number: 93-15-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- yes
- Remarks:
- poorly documented
- GLP compliance:
- no
- Specific details on test material used for the study:
- Purity of each material was checked in the Organic Chemicals Synthesis Laboratory, AEQI, in Beltsville by gas chromatography: > 98%
- Analytical monitoring:
- not specified
- Vehicle:
- yes
- Remarks:
- Acetone
- Test organisms (species):
- other: Rainbow trout (cold water fish) and Bluegill (warm water fish)
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Nominal and measured concentrations:
- 5 concentrations from 3.2 to 10 mg/L.
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Vessels were lined with disposable polyethylene bags
- Type (delete if not applicable): open
- Material, size, headspace, fill volume: 12.5 L
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: 30 mg CaSO, 30 mg MgSO, 48 mg NaHCO, and 2 mg KC1 added per liter of deionized water.
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): Deaths and/or untoward behavioral reactions.
TEST CONCENTRATIONS
Range finding study : Data not published. - Reference substance (positive control):
- yes
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Rainbow trout
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 8.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Bluegill sunfish
- Results with reference substance (positive control):
- To check on suitability as test subjects, fish from each lot were challenged, under the same experimental conditions, with a reference pesticide (toxaphene, at 0.010, 0.018, and 0.056 ppm). The observed 96-hr LC50 was usually around 0.02 ppm; with one lot of bluegills there were no deaths at 0.018 ppm and no survivors at 0.056 ppm.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The 96h-LC50 was determined to be 6.0 mg/L for Rainbow trout and 8.1 mg/L for Bluegill sunfish.
- Executive summary:
An acute toxicity test was perfomed on Rainbow trous (cold water fish) and Bluegill sunfish (warm water fish). Vessels were lined with disposable polyethylene bags and filled with 12.5 liter reconstituted water. Ten fish were placed in each vessel and allowed 24 h to become acclimated. The test item solutions in acetone, were then added to the bioassay vessels. Five concentrations were tested on the basis of preliminary screening tests. Control groups of fish in untreated water and in water to which acetone only was added were observed concurrently. The fish were observed for 96 h and all deaths and/or untoward behavioral reactions were recorded. The concentration of dissolved oxygen was measured in all solutions in which deaths occurred to be sure the test water contained sufficient oxygen; dissolved oxygen concentrations above 4 mg/L for warm-water fish (bluegills) or above 5 mg/L for cold-water fish (rainbow trout) were considered adequate. The median lethal concentrations (LC50) were calculated. The 96h-LC50 was determined to be 6.0 mg/L (4.9 -7.2 mg/L) for Rainbow trout and 8.1 mg/L (7.4 -9.0 mg/L) for Bluegill sunfish.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- yes
- Remarks:
- poorly documented
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- 4-Allyl-1,2-dimethoxybenzene
- Analytical monitoring:
- yes
- Vehicle:
- not specified
- Test organisms (species):
- Oryzias latipes
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Nominal and measured concentrations:
- 10, 18, 32, 56, 100 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 3L
- Renewal rate of test solution (frequency/flow rate): 48h
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
OTHER TEST CONDITIONS
- Temperature: 24 ºC
Adjustment of pH: NO
- Photoperiod: 16h light / 8h dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): Mortality - Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 14.1 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- The 96h-LC50 was determined to be 14.1 mg/L (95% CL: 11.8-16.5 mg/L) in Oryzias latipes.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The 96h-LC50 was determined to be 14.1 mg/L in Oryzias latipes.
- Executive summary:
An acute fish test was performed according to the OECD Guideline 203 on Oryzias latipes. 10 fish per dose were exposed up to 100 mg/L test item for 96 hours under semi-static conditions. Test item was measured by HPLC analysis. The 96h-LC50 was determined to be 14.1 mg/L (95% CL: 11.8-16.5 mg/L) based on mortality.
Referenceopen allclose all
Description of key information
Key study: Test method similar to OECD 203. The 96h-LC50 was determined to be 6.0 mg/L for Rainbow trout and 8.1 mg/L for Bluegill sunfish.
Key study: Test method OECD 203. The 96h-LC50 was determined to be 14.1 mg/L in Oryzias latipes.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 6 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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