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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
yes
Remarks:
1h exposure, poorly documented
GLP compliance:
no
Test type:
traditional method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-allylveratrole
EC Number:
202-223-0
EC Name:
4-allylveratrole
Cas Number:
93-15-2
Molecular formula:
C11H14O2
IUPAC Name:
1,2-dimethoxy-4-(prop-2-en-1-yl)benzene
Test material form:
liquid
Specific details on test material used for the study:
Purity of each material was checked in the Organic Chemicals Synthesis Laboratory, AEQI, in Beltsville by gas chromatography: > 98%

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 150-240 g
- Fasting period before study: 16 hr before dosing.
- Housing: Individually in suspended wire-mesh cages.

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
whole body
Vehicle:
air
Duration of exposure:
1 h
Concentrations:
4.8 mg/L
No. of animals per sex per dose:
10
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 4.8 mg/L air
Based on:
test mat.
Exp. duration:
1 h

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The LC50 was determined to be >4.8 mg/L air after 1h exposure to aerosol in rats.
Executive summary:

Ten rats, caged separately to minimize filtration of inspired air by animal fur, were exposed for one hour to the aerosol generated from the undiluted test material by a pneumatic nebulizer. The average nominal concentrations of aerosol, the maximum attainable with the experimental equipment, were calculated by dividing the weight lost from the nebulizer by the total volume of air used (in milligrams per liter air) and it results to be 4.8 mg/L air. Following exposure, the animals were observed for 14 days. The LC50 was determined to be >4.8 mg/L air after 1h exposure to aerosol in rats.