Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 942-754-1 | CAS number: -
Endpoint summary
Administrative data
Description of key information
The bioconcentration factor (BCF) of the registered substance in the rainbow trout was determined, by read-across, to be 560 and the depuration half-life was determined at 2.0 days (OECD Guideline 305). Nevertheless, this result seems to be overestimated because the BCF was based upon total radiolabelled residues without separating the degradation of the substance from that of the metabolites over the 28 day (maximum accumulation in fish) and 35 day (total depuration) test period. In many cases metabolites are incorporated into the fish tissue in the same way as food and a BCF of 560 can be considered as a worst case value.
In addition, an in vitro biotransformation assay using liver S9 fractions and hepatocytes from rainbow trout (Oncorhynchus mykiss) was performed on the same read-across substance. Based on the results of this study, the predicted in vivo BCF values using the model of Nichols et al., 2013, were determined at 363 L/kg and 196 L/kg for the RT-S9 and RT-HEP assays, respectively. The study was finalised, submitted to Journal of Applied Toxicology, but not yet published. The dossier will be updated as soon as the report is made available. In conclusion, the average BCF value was determined at 373 L/kg. The result indicates that the registered substance did not bioaccumulate in the rainbow trout.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
