Registration Dossier

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
December 18, 2013 - July 17, 2014
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study was performed in accordance with OECD guideline 105. The analytical method and the nominal concentrations were not in agreement with the guideline but these are well documented in the study report.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2014
Report Date:
2014

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
(1995)
Principles of method if other than guideline:
No preliminary test was performed.

The factor of saturation (concentration nominal/concentration analysed) was < 5: the water solubility of 48.5 wt% is at approximate at the same level as the nominal concentrations of 50 -53 wt%. From this it was assumed that the actual water solubility might be higher than as was measured during this study.

The analytical method, i.e. refractive index measurements, is not substance specific. The influence of (good soluble) impurities cannot be excluded. The obtained result should therefore be interpreted as an estimated value for the water solubility of the substance.
GLP compliance:
no
Type of method:
flask method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
Name of test material (as cited in study report): Disodium Isodecyl Sulfosuccinate
Description: white powder
Storage conditions of test material: at room temperature in well-sealed container
The substance was tested as received.

Results and discussion

Water solubility
Water solubility:
>= 485 g/L
Temp.:
20 °C
pH:
5.5

Any other information on results incl. tables

Table: Refractive Index results of the diluted supernatants from the water solubility test

A

B

C

 

Supernatant wt (g)

Total wt in water (g)

Refractive Index of dilution at 20°C

Calculated solubility*

[wt%]

Equilibrium Time (Days)

1.4468

2.8941

1.369808

48.5

1

1.2018

2.4661

1.368855

48.5

1

2.0139

6.4121

1.355607

48.3

2

3.0147

6.0939

1.369253

48.3

2

1.4897

3.4168

1.365019

48.6

3

1.5066

3.3499

1.366144

48.7

3

 

 

 

 

 

Average wt%

48.5

 

S.D.

0.17

 

* Water solubility = (C*640.0873942-852.5511009)*B/C [wt%]

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): very soluble (> 10000 mg/L)
In a OECD 105 guideline study using the flask method followed by refractive index measurements, the water solubility at 20°C of the substance was estimated to be ≥485 g/L. The pH of the aqueous phase was 5.5.