Cobalt di(acetate)

Toxicity to birds

Administrative data

Endpoint:

short-term toxicity to birds: dietary toxicity test

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study accepted by U.S. authorities and WHO.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Influence of high levels of minerals on the susceptibility of chicks to Salmonella gallinarum

Author:

Hill CH

Year:

1974

Bibliographic source:

Journal of Nutrition 104(10):1221–1226

Reference 2

Reference Type:

secondary source

Title:

CICAD 69, Cobalt and inorganic cobalt compounds

Author:

WHO

Year:

2006

Reference 3

Reference Type:

secondary source

Title:

Ecological soil screening levels for Cobalt

Author:

U.S. EPA

Year:

2005

Bibliographic source:

Washington, DC, United States Environmental Protection Agency, Office of Solid Waste and Emergency Response, 57 pp. (OSWER Directive 9285.7-67; http://www.epa.gov/ecotox/ecossl/pdf/eco-ssl_cobalt.pdf).

Materials and methods

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Cobalt dichloride, hexahydrate

IUPAC Name:

Cobalt dichloride, hexahydrate

Constituent 2

Reference substance name:

7791-13-1

EC Number:

616-574-6

Cas Number:

7791-13-1

IUPAC Name:

7791-13-1

Details on test material:

- Analytical purity: no data

Dose method:

feed

Analytical monitoring:

no

Vehicle:

no

Test organisms

Test organisms (species):

other: Gallus domesticus

Study design

Limit test:

no

Total exposure duration (if not single dose):

14 d

Nominal and measured doses / concentrations:

0, 50, 100, 200, 300, 400 ppm Co

Results and discussion

Effect levels

Effect levels 1

Duration (if not single dose):

14 d

Dose descriptor:

NOEL

Effect level:

50 mg/kg diet

Conc. / dose based on:

element

Remarks:

Co

Basis for effect:

body weight

Effect levels 2

Duration (if not single dose):

14 d

Dose descriptor:

LOEL

Effect level:

100 mg/kg diet

Conc. / dose based on:

element

Remarks:

Co

Basis for effect:

body weight