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Description of key information

Both in vitro and in vivo studies were performed in a tiered testing approach, demonstrating that tin sulfide and tin disulfide are not corrosive or irritating to skin and eye.

Based on this information it is considered that also ditin trisulfide reveals no skin or eye irritating/corrosive effect.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Read-Across Justification_SnS and SnS2 to Sn2S3
Reason / purpose for cross-reference:
read-across source
Irritation parameter:
erythema score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Irritation parameter:
edema score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Irritation parameter:
edema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Irritant / corrosive response data:
There was no erythema or edema noted for any animal at any observation period.
There were no abnormal physical signs noted during the observation period and all body weights were normal. Therefore the test item tin sulfide is not a dermal irritant.
Other effects:
No abnormal physical signs were noted during the observation period.
Interpretation of results:
not irritating
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
Read-across substance tin sulfide had no skin irritating/corrosive effects in an in vivo study according to OECD guideline 404.
Based on this information it is considered that also ditin trisulfide reveals no skin irritating or corrosive effect.
Executive summary:

A skin irritation/corrosion study with rabbits according to OECD guideline 404 was performed to determine the irritant or corrosive effects, if any, of read-acrosss substance tin sulfide when applied to the skin. There was no erythema or edema noted for any animal at any observation period. Test item stained the dose sites at all observation periods. There were no abnormal physical signs noted during the observation period. All body weights were normal.

Based on this information it is considered that also ditin trisulfide reveals no skin irritating or corrosive effect.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Read-Across Justification_SnS and SnS2 to Sn2S3
Reason / purpose for cross-reference:
read-across source
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Score:
0.67
Max. score:
110
Reversibility:
fully reversible within: 48 h
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
48 h
Score:
0
Max. score:
110
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
72 h
Score:
0
Max. score:
110
Irritation parameter:
overall irritation score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Max. score:
110
Irritation parameter:
overall irritation score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Max. score:
110
Irritation parameter:
overall irritation score
Basis:
animal #3
Time point:
24 h
Score:
2
Max. score:
110
Reversibility:
fully reversible within: 48 h
Irritation parameter:
overall irritation score
Basis:
animal #3
Time point:
48 h
Score:
0
Max. score:
110
Irritation parameter:
overall irritation score
Basis:
animal #3
Time point:
72 h
Score:
0
Max. score:
110
Irritation parameter:
cornea opacity score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Max. score:
80
Irritation parameter:
cornea opacity score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Max. score:
80
Irritation parameter:
cornea opacity score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Max. score:
80
Irritation parameter:
iris score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Max. score:
10
Irritation parameter:
iris score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Max. score:
10
Irritation parameter:
iris score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Max. score:
10
Irritation parameter:
conjunctivae score
Remarks:
redness
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Max. score:
3
Irritation parameter:
conjunctivae score
Remarks:
redness
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Max. score:
3
Irritation parameter:
conjunctivae score
Remarks:
redness
Basis:
animal #3
Time point:
24/48/72 h
Score:
0.333
Max. score:
3
Reversibility:
fully reversible within: 48 h
Irritation parameter:
chemosis score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
chemosis score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
chemosis score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritant / corrosive response data:
There was no corneal opacity or iritis noted at any observation period. Conjunctival irritation, noted in 3/3 eyes after 1 hour, cleared in two animals by 24 hours and in all animals by 48 hours. The control eyes were normal at all observation periods. There were no abnormal physical signs noted during the observation period. Body weights increased in 2/3 animals and stayed the same in one animal.
Interpretation of results:
GHS criteria not met
Conclusions:
Tin sulfide had no eye irritating/corrosive effect in an in vivo study according to OECD guideline 405.
Based on this information it is considered that also ditin trisulfide reveals no eye irritating/corrosive effect.
Executive summary:

The eye irritating/corrosive properties of tin sulfide were determined in a study with rabbits according to OECD guideline 405. There was no corneal opacity or iritis noted at any observation period. Conjunctival irritation, noted in 3/3 eyes after 1 hour, cleared in two animals by 24 hours and in all animals by 48 hours. There were no abnormal physical signs noted during the observation period. In summary, the mean total score at 24 hours was 0.67, at 48 and 72 hours it was 0.

Based on this information it is considered that also ditin trisulfide reveals no eye irritating/corrosive effect.

 

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Skin in vitro/in vivo:

Tin sulfide and tin disulfide had no skin irritating/corrosive effects in in vitro studies according to OECD guidelines 439 and 431 as well as in an in vivo study according to OECD guideline 404.

Based on this information it is considered that also ditin trisulfide reveals no skin irritating/corrosive effect.

 

Eye in vitro/in vivo:

Tin sulfide and tin disulfide had no eye irritating/corrosive effect in in vitro studies (HET-CAM) and in in vivo studies according to OECD guideline 405.

Based on this information it is considered that also ditin trisulfide reveals no eye irritating/corrosive effect.

 

 

Justification for selection of skin irritation / corrosion endpoint:

GLP and guideline compliant study on a structural analogous read-across substance

 

Justification for selection of eye irritation endpoint:

GLP and guideline compliant study on a structural analogous read-across substance

Justification for classification or non-classification

Based on skin and eye irritation/corrosion data available for tin sulfide and tin disulfide no classification and labelling for ditin trisulfide is required according to Regulation No (EC) 1272/2008 (CLP) or Directive 67/548/EEC (DSD) criteria.