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Key value for chemical safety assessment

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A technique was developed to determine partition coefficients for low-molecular-weight, volatile compounds such as the test substance. The liquid:air and tissue:air partitions were determined in 0.9% saline, in olive oil, and in blood, liver, muscle, and fat tissues from rats. Human blood:air values were also determined. The test substance, as a vapour, was mixed with the matrix then incubated for 15 minutes to allow for equilibration. Samples of the headspace were analysed by gas chromatography and the partition coefficient determined. 

 

Values were:

Human blood:air = 6.04±0.38

Rat blood:air = 9.58±0.94

Saline:air =1.41±0.04

Olive oil:air = 178±6

Rat fat:air = 148±11

Rat liver:air = 8.96±0.61

Rat muscle:air = 3.52±0.54