Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-860-2 | CAS number: 156-60-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Data taken from accepted publication with limited details on methods and results. This study was selected as the key study because the information provided for the hazard endpoint is sufficient for the purpose of classification and labelling and/or risk assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- The acute and subchronic toxicity in rats of trans-1,2-dichloroethylene in drinking water
- Author:
- Hayes JR, Condie LW Jr, Egle JL Jr and Borzelleca JF
- Year:
- 1 987
- Bibliographic source:
- J. Am. Coll. Toxicol., 6:471-478
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Deviations:
- yes
- Remarks:
- dose levels not reported
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- trans-dichloroethylene
- EC Number:
- 205-860-2
- EC Name:
- trans-dichloroethylene
- Cas Number:
- 156-60-5
- Molecular formula:
- C2H2Cl2
- IUPAC Name:
- (1E)-1,2-dichloroethene
- Details on test material:
- - Purity: 98%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Sprague-Dawley derived CD, Charles River
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 22-30 days
- Weight at study initiation: Male and female rats, weighing 113 ± 5 g and 102 ± 2 g, respectively
- Fasting period before study: fasted overnight (water but no feed, 16 hours) before dosing
- Housing: stainless steel wire-bottomed suspended cages
- Diet: Purina Rodent Chow No. 5001, ad libitum
- Water: ad libitum
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21-24°C
- Humidity (%): 40-60%
- Photoperiod (hrs dark / hrs light): 12-hour light-dark cycle
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 450-850 mg/mL
MAXIMUM DOSE VOLUME APPLIED: volume of solution administered was 10 mL/kg - Doses:
- not reported
- No. of animals per sex per dose:
- five dosage groups consisting of 10 rats per sex per group
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Hourly observations were made during the first 9 hours after administration, followed by twice daily (at least 5 hours apart) observations for the next 14 days.
- Necropsy of survivors performed: yes - Statistics:
- The LD50 was determined by the method of Litchfield and Wilcoxon.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 7 902 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 6 805 - 9 175
- Remarks on result:
- other: Dose-dependent central nervous system depression, ataxia, and depressed respiration observed at all doses
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 9 939 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 6 494 - 15 213
- Remarks on result:
- other: Dose-dependent central nervous system depression, ataxia, and depressed respiration observed at all doses
- Mortality:
- All deaths occurred within 30 hours after dosing.
- Clinical signs:
- other: Central nervous system depression, ataxia, and depressed respiration were observed at all doses; the severity was dose dependent.
- Gross pathology:
- Gross necropsy findings of all rats that died were essentially negative. No consistent compound-related gross pathological findings were observed at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- This study and the conclusions which are drawn from it fulfil the quality criteria (validity, reliability, repeatability).
LD50 Male Rats = 7902 mg/kg
LD50 Female Rats = 9939 mg/kg - Executive summary:
To determine the LD50 in rats, the test item was administered by gavage to male and female Sprague-Dawley derived Charles River rats. Male and female rats were divided into five dosage groups consisting of 10 rats per sex per group. After administration, hourly observations were made during the first 9 hours then followed by twice daily (at least 5 hours apart) observations for the next 14 days. All deaths occurred within 30 hours after dosing. Central nervous system depression, ataxia, and depressed respiration were observed at all doses; the severity was dose dependent. Gross necropsy findings of all rats that died were essentially negative. No consistent compound-related gross pathological findings were observed at necropsy. The LD50s for male and female rats were 7902 and 9939 mg/kg, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.