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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Principles of method if other than guideline:
A Method for Determining the Dermal Taxicity of Pesticides; Brit.Journ.Ind.Med. 26, 59, 1969
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium 4-[(2-hydroxy-1-naphthyl)azo]benzenesulphonate
EC Number:
211-199-0
EC Name:
Sodium 4-[(2-hydroxy-1-naphthyl)azo]benzenesulphonate
Cas Number:
633-96-5
Molecular formula:
C16H12N2O4S.Na
IUPAC Name:
sodium;4-[(2E)-2-(2-oxonaphthalen-1-ylidene)hydrazinyl]benzenesulfonate

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
initial body weight: 150g males, 130g females
source: SPF Zucht, Wiga

Administration / exposure

Type of coverage:
not specified
Vehicle:
water
Remarks:
50%
Details on dermal exposure:
50cm2, at the back
Duration of exposure:
not described
Doses:
2500 mg/kgbw
No. of animals per sex per dose:
5
Details on study design:
post-observation period 14 days

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 500 mg/kg bw
Based on:
test mat.
Mortality:
no
Gross pathology:
no findings
Other findings:
remaining orange material at the applicaion site

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The tested item was found to be non-toxic for dermal exposure with a LD50 > 2500 mg/kg bw.
Executive summary:

The acute oral toxicity of Acid Orange 7 in rats of both sexes was assessed with this test following OECD 402 guidelines.
The LD50 value was > 2000 mg/kg.