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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1974
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: brief documentation, no substance identity verification, no relevant route of exposure

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium 4-[(2-hydroxy-1-naphthyl)azo]benzenesulphonate
EC Number:
211-199-0
EC Name:
Sodium 4-[(2-hydroxy-1-naphthyl)azo]benzenesulphonate
Cas Number:
633-96-5
Molecular formula:
C16H12N2O4S.Na
IUPAC Name:
sodium 4-[(2-hydroxy-1-naphthyl)azo]benzenesulphonate

Test animals

Species:
mouse
Strain:
NMRI
Sex:
male/female
Details on test animals or test system and environmental conditions:
inital body weight: 25.6 g males, 22.1g females

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
CMC (carboxymethyl cellulose)
Remarks:
0.5%
Details on exposure:
15% solution
Doses:
1000 and 2150 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
7 days post-observation period

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 000 mg/kg bw
Mortality:
at 1000 mg/kg bw: 2/5 males and 3/5 females within 24h
at 2150 mg/kg bw: 5/5 males and 3/5 females within 24h
Clinical signs:
at 1000 mg/kg bw: prone position, dyspnoea, discolored skin (ears, tail), apathy, tremor, staggered gait
at 2150 mg/kg bw: prone position, dyspnoea, discolored skin (ears, tail) and urine, agressive, tremor, staggered gait
Body weight:
regular body weight gain
Gross pathology:
remaining substance intra-abdominal one day after application, no substance after 7 days

Applicant's summary and conclusion