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Dissociation constant

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Description of key information

OECD Guideline 112_Dissociation coefficient (pKa value): 1.79 ± 0.1 (first ionisation constant); 7.01 ± 0.1 (second ionisation constant) at 25°C.

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Additional information

The dissociation coefficient (pKa value) of the test compound was determined experimentally in compliance with OECD Guideline 112. The determination was carried out using a Potentiometric Titration Method. Prior to testing, the potentiometer was standardised using pH 4, 7 and 10 buffers of known certified pH at 20°C. The dissociation coefficient (pKa value) of the test compound has been determined to be 1.79 ± 0.1 (first ionisation constant) and 7.01 ± 0.1 (second ionisation constant) at 25 ± 1.0°C.