Registration Dossier
Registration Dossier
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EC number: 205-003-2 | CAS number: 130-95-0
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 11.1 µg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 111 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 1.11 µg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 2.83 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.283 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 2.83 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- insufficient hazard data available (further information necessary)
Additional information
The determined aquatic toxicity of quinine sulphate to Ictalurus punctatus is 34 mg/L (LC50, 96 h). According to this, the LC50 (96 h) of quinine is 26.1 mg/L.
The aquatic toxicity of quinine to invertebrates was determined experimentally and published by Guilhermino, 2000. The EC50 of the read across substance quinine sulphate for Daphnia magna was determined in freshwater. The EC50 (24 h) of quinine sulphate for Daphnia magna is 44.8 mg/l. According to this, the EC50 of quinine is 34.4 mg/L.In an own experimental study the EC50 for 48 h of the read across substance quinine sulphate for Daphnia magna is 91.93.mg/l. According to this, the EC50 of quinine is 70.59 mg/l. The aquatic toxicity to algae was also determined experimentally and published by Moreno-Garrido, 2001. In this publication, the toxicity for green algaeDunaliella salinawas determined for 72 h in saltwater. The determined EC50 of the read across substance quinine sulphate is 14.5 mg/L. According to this, the EC50 of quinine is 11.13 mg/L.
Conclusion on classification
The experimentally determined LC50/EC50 of quinine for fish, invertebrates and algae is > 10 mg/L and furthermore quinine is readily biodegradable. According to CLP 1272/2008 criteria for acute (short-term) aquatic toxicity, only substance with a toxicity of LC50/EC50 < 1 mg/L has to be classified. Therefore, quinine is not harmful to aquatic life and does not need to be classified.
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