Quinine

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comprehension of case reports.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

publication

Title:

The value of corneal peeling or corneal resection in ophthalmology.

Author:

Kilgore, G. L.

Year:

1946

Bibliographic source:

Trans Am Ophthalmol Soc. 44:100-112

Materials and methods

Type of study / information:

Case report

Endpoint addressed:

eye irritation

Principles of method if other than guideline:

The use of quinine bisulphate ointment, 2 %, for several years as a clarifier of corneal opacities is described in two case reports.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Automatically generated during migration to IUCLID 6, no data available

IUPAC Name:

Automatically generated during migration to IUCLID 6, no data available

Test material form:

not specified

Details on test material:

- Name of test material (as cited in study report): quinine bisulphate

Method

Ethical approval:

not applicable

Details on study design:

Case 1- Sex: male- Age: 33- History: Quicklime was splashed in both eyes when he was seven years of age.- Symptoms, onset and progress of the disease: Vision of right eye is 20/200, left eye 5/200- Other: A corneal resection was performed on the right eye, with removal of a horizontal band of scar tissue four mm wide and one-half mm thick from in front of the pupil. A similar horizontal band of scar tissue four mm wide and one-half mm thick was removed from the corneal surface of the left eye. Quinine bisulphate ointment (2 %) was used in each eye for a short timeCase 2- Sex: male - Age: 40- History: Patient had a gonococcal infection of each eye with ulceration of the cornea of each eye and loss of left globe from panophthalmitis. - Other: A corneal peeling operation was done under cocaine anaesthesia. A cross incision was made in the cornea to a depth of three-quarters mm followed by dissecting the four quadrants free and off. There was a small break in the epithelial covering near the centre of the cornea. Quinine bisulphate ointment (2%) were prescribed for use twice a day.

Exposure assessment:

measured

Results and discussion

Results:

Quinine bisulphate ointment has been used for a number of years as a clarifier of corneal opacities through its destruction of lymphocytes and leukocytes. Therefore, a 2 % quinine bisulphate ointment was used post-operative to improve the regeneration. Thus, we conclude that quinine is not irritating to eyes.

Applicant's summary and conclusion

Conclusions:

Quinine bisulphate ointment has been used for a number of years as a clarifier of corneal opacities. Therefore, in the two case reports a 2 % quinine bisulphate ointment was used post-operative to improve the regeneration. Thus, we conclude that quinine is not irritating to eyes.

Executive summary:

Quinine bisulphate ointment has been used for a number of years as a clarifier of corneal opacities through its destruction of lymphocytes and leukocytes. Therefore, in the two case reports a 2 % quinine bisulphate ointment was used post-operative to improve the regeneration. Thus, we conclude that quinine is not irritating to eyes.