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EC number: 942-795-5 | CAS number: -
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
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Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 48 hours
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- - Source: Aquatic BioSystems (Fort Collins, CO)
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Post exposure observation period:
- Day 0, Day 1 and Day 2
- Hardness:
- 104 mg/L as CaCO3
- Test temperature:
- 19.2-21.1˚C
- pH:
- 7.6-8.2
- Dissolved oxygen:
- 9.0-9.5 mg/L
- Nominal and measured concentrations:
- Nominal concentrations of the test item are 6.25 mg/L, 12.5 mg/L, 25mg/L, 50 mg/L and 100mg/L
- Details on test conditions:
- - Test vessel: ~250 mL glass beakers
- Test volume: 200 mL
- Aeration: None
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- Photoperiod: 16-hr light: 8-hr dark with a 30 minute transition period
- Light intensity: 687-773 lux - Reference substance (positive control):
- yes
- Remarks:
- Zinc sulphate heptahydrate (CAS NO. 7446-20-0)
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 70.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- - LC50 for 48hr: 0.48 mg Zn2+/L
- Validity criteria fulfilled:
- yes
- Conclusions:
- According to OECD 202 test method, the 48-hr EC50 of CJ301 was 70.7mg/L.
- Executive summary:
This test using the procedures outlined in the Maxxam Study Plan for TOX1602 which is based on the SOP for the OECD 202 (BBY2SOP-00017) and OECD 202 (OECD, 2004). The results of this OECD 202 test for CJ301 show that all validity criteria were met.
Based on the nominal concentrations of CJ301:
1. The 48-hr EC50 was 70.7 mg/L with the 95% confidence limits of 50 mg/L and 100mg/L.
2. The NOEC and LOEC was 50 mg/L and 100 mg/L, respectively.
Reference
The 0% of control organisms were immobilised and the dissolved oxygen concentration at the end of the test was 9.0-9.1 mgO2/L. The initial pH measurements did not differ from the final measurements by more than 1.5 units in each test. The color of the test solutions remained the same throughout the test..
Table 1. Number and Percentage of Daphnia Immobilised after 24-hr Exposure
Nominal Concentration of Test Item (mg/L) |
Mean ± SD (%) |
Replicate A (# / %) |
Replicate B (# / %) |
Replicate C (# / %) |
Replicate D (# / %) |
0 (Neg./Lab. Control) |
0 ± 0 |
0 / 0 |
0 / 0 |
0 / 0 |
0 / 0 |
6.25 |
0 ± 0 |
0 / 0 |
0 / 0 |
0 / 0 |
0 / 0 |
12.5 |
0 ± 0 |
0 / 0 |
0 / 0 |
0 / 0 |
0 / 0 |
25 |
0 ± 0 |
0 / 0 |
0 / 0 |
0 / 0 |
0 / 0 |
50 |
0 ± 0 |
0 / 0 |
0 / 0 |
0 / 0 |
0 / 0 |
100 |
0 ± 0 |
0 / 0 |
0 / 0 |
0 / 0 |
0 / 0 |
Table 2. Number and Percentage of Daphnia Immobilised after 48-hr Exposure
Nominal Concentration of Test Item (mg/L) |
Mean ± SD (%) |
Replicate A (# / %) |
Replicate B (# / %) |
Replicate C (# / %) |
Replicate D (# / %) |
0 (Neg./Lab. Control) |
0 ± 0 |
0 / 0 |
0 / 0 |
0 / 0 |
0 / 0 |
6.25 |
0 ± 0 |
0 / 0 |
0 / 0 |
0 / 0 |
0 / 0 |
12.5 |
0 ± 0 |
0 / 0 |
0 / 0 |
0 / 0 |
0 / 0 |
25 |
0 ± 0 |
0 / 0 |
0 / 0 |
0 / 0 |
0 / 0 |
50 |
0 ± 0 |
0 / 0 |
0 / 0 |
0 / 0 |
0 / 0 |
100 |
100 ± 0 |
5 / 100 |
5 / 100 |
5 / 100 |
5 / 100 |
Table 3. Test Endpoint Summary for CJ301
Concentration (mg/L) |
CJ301 (mg/L) |
||
48-hr EC50 |
LOEC |
NOEC |
|
Nominal |
70.7 |
100 |
50 |
Description of key information
The 48-hr EC50 of CJ301 was 70.7mg/L for Daphnia magna (OECD TG202).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 70.7 mg/L
Additional information
The test was considered valid as 0% of control organisms were immobilised and the minimum dissolved oxygen concentration at the end of the test was 9.0-9.1 mg O2/L. All test validity criteria were met. The pH of the test solutions was within the ranges outlined in the OECD 202 test guideline. The measured concentrations of CJ301 were within 80-120% of their nominal concentrations.
Based on the nominal concentrations of CJ301:
1. The 48-hr EC50 was 70.7 mg/L with the 95% confidence limits of 50 mg/L and 100mg/L.
2. The NOEC and LOEC was 50 mg/L and 100 mg/L, respectively.
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