Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: well performed OECD study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2015
Report date:
2015

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
no
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
2-hydroxy-1-naphthaldehyde
EC Number:
211-902-0
EC Name:
2-hydroxy-1-naphthaldehyde
Cas Number:
708-06-5
Molecular formula:
C11H8O2
IUPAC Name:
2-hydroxy-1-naphthaldehyde
Details on test material:
purity: 99,6 %

Results and discussion

Water solubility
Water solubility:
22 mg/L
Temp.:
20 °C
pH:
ca. 5

Any other information on results incl. tables

Flask No. Equilibration time pH of aqueous Test substance

at 20°C [h] solution content [mg/L]

1 24 5,0 23

2 48 5,1 21

3 72 5,2 23

mean --- --- 22

HPLC conditions:

Column : Ascentis Express C8, 150 mm x 4,6 mm ID, 2,7 /lm

Eluent A : water + 0,1% (v/v) formic acid; Eluent B : acetonitrile

Gradient

: 0 min 10% B

: 8 min 10% B

: 8,1 min 82% B

: 13 min 10% B

Flow rate: 1.2 ml/min

Temperature: 40 °C

Detector: UV, 220 nm

Inj. Volume: 5 µL

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The water solubility of the substance is 22 mg/L at 20°C.
Executive summary:

The water solubility of the substance was determined according to OECD guideline 105 (flask method). Analytics was performed by HPLC. The water solubility was found to be 22 mg/L at 20°C.

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