Triethoxy(3-isocyanatopropyl)silane

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

No data available

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

yes

Remarks:

(4 animals per dose group (at least 5 recommended), 2 doses (at least 3 recommended), immobilisation not recommended, occlusive application (semi-occlusive recommended), insufficient details to further judge compliance with test guideline)

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Triethoxy(3-isocyanatopropyl)silane

EC Number:

246-467-6

EC Name:

Triethoxy(3-isocyanatopropyl)silane

Cas Number:

24801-88-5

Molecular formula:

C10H21NO4Si

IUPAC Name:

triethoxy(3-isocyanatopropyl)silane

Test animals

Species:

rabbit

Strain:

other: albino

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: no data available
- Age at study initiation: 3 to 5 months
- Weight at study initiation: no data available
- Fasting period before study: no data available
- Housing: no data available
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data available

ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data available
- Humidity (%): no data available
- Air changes (per hr): no data available
- Photoperiod (hrs dark / hrs light): no data available

IN-LIFE DATES: no data available

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

TEST SITE
- Area of exposure: no data available
- % coverage: no data available
- Type of wrap if used: impervious sheeting

REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data available
- Time after start of exposure: no data available

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1 or 2 ml/kg bw [980 or 1970 mg/kg bw]
- Constant volume or concentration used: no data available

Duration of exposure:

24 Hours

Doses:

1 or 2 ml/kg bw [980 or 1970 mg/kg bw]

No. of animals per sex per dose:

4 males

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data available
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, skin irritation

Statistics:

No data available

Results and discussion

Preliminary study:

No data available

Effect levels

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

1.26 mL/kg bw

Based on:

test mat.

95% CL:

>= 0.772 - < 2.06

Remarks on result:

other: Density 1.0007 g/ml; 1.26 ml/kg bw is equivalent to 1261 mg/kg bw; 4/4 deaths at 2 ml/kg bw, 1/4 deaths at 1 ml/kg bw

Mortality:

1/4 animals given 1 mlkg died (on day 2)
4/4 animals given 2 ml/kg died (on day 1)

Clinical signs:

other: No clinical signs were reported for animals given 1.0 ml/kg bw In animals given 2 ml/kg bw, rapid breathing and irritability were noted within the first few hours of treatment

Gross pathology:

Congestion of the lungs
Spleens, livers and kidneys pale
Livers and kidneys mottled

Other findings:

- Other observations: skin erythema and oedema were reported in animals given 1 ml/kg bw. Skin erythema and ecchymosis were reported in animals given 2 ml/kg bw

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

In a study probably similar to that described by OECD Test Guideline 402, triethoxy(3-isocyanatopropyl)silane was harmful to male rabbits following a 24-hour acute dermal administration. An acute dermal LD50 of 1.26 ml/kg bw [1261 mg/kg bw] was derived.

Executive summary:

Two summary reports described an acute dermal toxicity study in rabbits, probably similar to that described by OECD Test Guideline 402 (acute dermal toxicity), with triethoxy(3-isocyanatopropyl)silane.

Groups of four male albino rabbits were exposed to undiluted triethoxy(3-isocyanatopropyl)silane at 1 or 2 ml/kg bw under occlusion for 24 hours. Rabbits were observed for 14 days for mortality and clinical signs of toxicity, before sacrifice and necropsy to identify any gross pathological changes.

One and four animals died in the low and high dose groups respectively. Congestion was noted in the lungs, as well as paleness and mottling in livers and kidneys, and pale spleens. Irritability and rapid breathing were noted in animals from the top dose group within the first few hours of treatment. Skin erythema was seen in all treated animals, while ecchymosis [haemorrhagic spots] was seen in animals treated with 2 ml/kg bw, and oedema in animals given 1 ml/kg bw.

Triethoxy(3-isocyanatopropyl)silane was harmful to male rabbits and an acute dermal LD50 of 1.26 ml/kg bw [1240 mg/kg bw] was derived.