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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1972
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically acceptable study report

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1972
Report date:
1972

Materials and methods

Principles of method if other than guideline:
Single intraperitoneal application with 7-day observation period
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Hydrogen [tris[[[3-[(2-ethylhexyl)oxy]propyl]amino]sulphonyl]-29H,31H-phthalocyaninesulphonato(3-)-N29,N30,N31,N32]cuprate(1-), compound with 3-[(2-ethylhexyl)oxy]propylamine (1:1)
EC Number:
304-661-9
EC Name:
Hydrogen [tris[[[3-[(2-ethylhexyl)oxy]propyl]amino]sulphonyl]-29H,31H-phthalocyaninesulphonato(3-)-N29,N30,N31,N32]cuprate(1-), compound with 3-[(2-ethylhexyl)oxy]propylamine (1:1)
Cas Number:
94277-77-7
Molecular formula:
C65 H84 Cu N11 O12 S4 .C11 H25 N O .H
IUPAC Name:
copper(2+) hydrogen 3-[(2-ethylhexyl)oxy]propan-1-amine 14,24,32-tris({[({3-[(2-ethylhexyl)oxy]propyl}amino)oxy]sulfonyl})-2,11,20,29,37,38,39,40-octaazanonacyclo[28.6.1.1³,¹⁰.1¹²,¹⁹.1²¹,²⁸.0⁴,⁹.0¹³,¹⁸.0²²,²⁷.0³¹,³⁶]tetraconta-1,3(40),4,6,8,10,12,14,16,18,20,22,24,26,28(38),29,31,33,35-nonadecaene-37,39-diide-5-sulfonate
Details on test material:
Name of the test substance used in the study report: Neozaponblau FLE (61-3236)

Test animals

Species:
mouse
Strain:
NMRI
Sex:
male/female
Details on test animals or test system and environmental conditions:
Mean body weight: males 25.6 g, females 21.3 g

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
CMC (carboxymethyl cellulose)
Details on exposure:
Aqueous suspension with CMC
Test concentration used: 16% (G/V)
Doses:
800, 1000, 1250, 1600, 2000, 2500 and 3200 mg/kg
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Intra-abdominal substance residues were observed at necropsy
Mortality:
800, 1000 and 1250 mg/kg: no deaths after 7 days; 1600 mg/kg: 1/10 after 7 days; 2000 mg/kg: 5/10 after 7 days; 2500 and 3200 mg/kg: 5/5 after 7 days
Clinical signs:
Dyspnea, atony, convulsions
Gross pathology:
Intra-abdominal substance residues

Applicant's summary and conclusion

Conclusions:
The LLD50 for a single intraperitoneal injection to mice is 2000 mg/kg bw. No mortality was observed at doses of 800, 1000 and 1250 mg/kg bw. The observation period was 7 days.