Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Increased dominant-lethal effects due to prolonged exposure of mice to inhaled ethylene oxide.
Author:
GENEROSO, W.M., CUMMING, R.B., BANDY, J.A., & CAIN, K.T.
Year:
1983
Bibliographic source:
Mutat. Res., 119: 377-379

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
Type of assay:
rodent dominant lethal assay

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethylene oxide
EC Number:
200-849-9
EC Name:
Ethylene oxide
Cas Number:
75-21-8
Molecular formula:
C2H4O
IUPAC Name:
oxirane

Test animals

Species:
mouse

Administration / exposure

Route of administration:
inhalation

Results and discussion

Test results
Sex:
not specified
Genotoxicity:
positive
Toxicity:
not specified

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): positive