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Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
02 June 2015-18 August 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP-compliant study in accordance with EC A.4 and OECD 104.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2015
Report date:
2015

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
(2009)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
(2006)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Version / remarks:
(1996)
Deviations:
no
GLP compliance:
yes
Type of method:
other: Effusion method: isothermal thermogravimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
(2S)-2-(1,3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-2-YL)PENTANEDIOIC ACID
EC Number:
608-945-6
Cas Number:
340-90-9
Molecular formula:
C13H11NO6
IUPAC Name:
(2S)-2-(1,3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-2-YL)PENTANEDIOIC ACID
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name (as cited in study report): Phthalyl-L-Glu
- Appearance: white powder
- Storage conditions: room temperature

Results and discussion

Vapour pressureopen allclose all
Temp.:
20 °C
Vapour pressure:
< 1.5 other: E-03 Pa
Temp.:
25 °C
Vapour pressure:
< 7 other: E-03 Pa
Temp.:
20 °C
Vapour pressure:
< 1.1 other: E-05 mm Hg
Temp.:
25 °C
Vapour pressure:
< 5.3 other: E-05 mm Hg

Any other information on results incl. tables

The weight losses of the test substance at 110°C, 120°C, 130°C and 140°C were lower than the weight losses of hexachlorobenzene at the same temperatures. From this it was concluded that vapour pressure of the substance at 20/25°C is lower than the vapour pressure of hexachlorobenzene at 20/25°C (see the table above).

Applicant's summary and conclusion

Conclusions:
In a GLP-compliant study in accordance with EC A.4, OECD 104 and EPA OPPTS 830.7950 using the isothermal thermogravimetric effusion method, the vapour pressure of the substance at 25°C has been determined as < 7.0E-03 Pa. The vapour pressure of the substance at 20°C has been determined as < 1.5E-03 Pa.