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EC number: - | CAS number: 8015-91-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: LD50 = 3458 mg/kg bw (similar to OECD401)
Acute dermal toxicity: LD50 = 702 mg/kg bw (similar to OECD402)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1972
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test was performed according to methods similar to OECD 401 and pre-GLP. Test seems reliable, but is very concise reported.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- 5 male/female used instead of 5 animals/sex
- GLP compliance:
- no
- Remarks:
- (pre-GLP)
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- other: Sherman Wistar (albino)
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 2034, 2543, 3214, 4069 and 5086 mg/kg bw
- No. of animals per sex per dose:
- 3 male, 2 female
- Control animals:
- no
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 458 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 2 950 - < 4 069
- Remarks on result:
- other: 3 out of 5 rats showed mortality at a dose of 3214 mg/kg bw, while no rats died in the lower dose groups. The LD50 was calculated based on these results.
- Mortality:
- No rats died in the two lowest dose groups (2034 and 2543 mg/kg bw). Mortality occurred in 3 out of 5 rats in the 3214 and 4069 mg/kg bw dose groups. All rats died in the higest dose group (5086 mg/kg bw). All mortality occurred on the first day after exposure.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this study, an LD50 of 3458 mg/kg bw was calculated. Therefore, the substance does not need to be classified as acute toxic via the oral route based on the criteria outlined in 1272/2008/EC (CLP).
- Executive summary:
The study was performed according to a method similar to OECD 401. 25 Sherman Wistar (albino) rats (15 male, 10 female) were dosed with varying doses of cinnamon bark oil via oral gavage. Test groups were administered with doses that ranged from 2034 to 5086 mg/kg bw with 5 rats in each group (3 male, 2 female). Rats were observed for 14 days after treatment.
No mortality was observed in the two lowest dose groups (2034 and 2543 mg/kg bw). Three out of 5 rats died at 3214 and 4069 mg/kg bw, while all rats died in the highest dose group (5086 mg/kg bw). All deaths occurred within 1 day after exposure. Based on these results a LD50 of 3458 mg/kg bw was calculated. Therefore, the substance does not need to be classified as acute toxic via the oral route based on the criteria outlined in Annex I of 1272/2008/EC (CLP).
Reference
Day | Mortality after 14 days | |||||||||||||||
Dosage level (mg/kg bw) | Number of test animals | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | |
2034 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
2543 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
3214 | 5 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 |
4069 | 5 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 |
5086 | 5 | 5 | - | - | - | - | - | - | - | - | - | - | - | - | - | 5 |
Overview of mortality
Mortality data was evaluated according to the Thompson Moving Average Method as described by Carrol S. Weil in the publication "Tables for Convenient Calculation of Median-Effective Dose (LD50 or ED50) and Instructions in Their Use" (Biometrics, Vol. 8, No. 3, pp. 249 -263, September 1952).
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 458 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1972
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test was performed according to methods similar to OECD 402 and pre-GLP. Test seems reliable, the test report is very concise but acceptable to fill this endpoint.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- only 2 animals used per dose instead of 5
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rabbit
- Strain:
- other: Albino
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: intact and abraded skin - Duration of exposure:
- Single exposure
- Doses:
- 321, 455, 641, 905 and 1282 mg/kg bw.
- No. of animals per sex per dose:
- 2
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no - Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 702 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 590 - < 834
- Remarks on result:
- other: 2 out of 2 rabbits showed mortality at a dose of 905 mg/kg bw and above, while no rabbits died in the lower dose groups. The LD50 was calculated based on these results.
- Mortality:
- No rabbits died in the three lowest dose groups with intact skin (321, 455 and 641 mg/kg bw). All animals (n=2) died within the first 4 days after
exposure in the 905 and the 1282 mg/kg bw dose group. - Clinical signs:
- other: No data
- Gross pathology:
- No data
- Other findings:
- No data
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this study, 2 out of 2 rabbits showed mortality at a dose of 905 mg/kg bw and higher, while no mortality was observed at 321, 455 and 641 mg/kg bw. Based on these results a LD50 of 702 mg/kg bw was calculated and therefore, the substance should be classified as acute toxic via the dermal route (Category 3 / H311) based on the criteria outlined in Annex I of 1272/2008/EC (CLP).
- Executive summary:
The study was performed according to a method similar to the OECD 402 guideline. Twenty albino rabbits (10 with abraded, 10 with intact skin, 2x2 rabbits per dose group) were exposed to 321, 455, 641, 905 or 1282 mg/kg bw cinnamon bark oil. Rabbits were observed for 14 days after treatment.
No mortality was observed in the three lowest dose groups with intact skin (321, 455 and 641 mg/kg bw). Mortality occurred within 4 days after exposure in all rabbits in the 905 and 1282 mg/kg bw dose groups. Based on these results a LD50 of 702 mg/kg bw was calculated and the substance should be classified as acute toxic via the dermal route (Category 3 / H311) given the criteria as outlined in Annex I of 1272/2008/EC (CLP).
Reference
Mortality data were evaluated according to the Thompson Moving Average Method as described by Carrol S. Weil in the publication "Tables for Convenient Calculation of Median-Effective Dose (LD50 or ED50) and Instructions in Their Use" (Biometrics, Vol. 8, No. 3, pp. 249 -263, September 1952).
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 702 mg/kg bw
Additional information
Acute oral toxicity
The study was performed according to a method similar to OECD 401. 25 Sherman Wistar (albino) rats (15 male, 10 female) were dosed with varying doses of cinnamon bark oil via oral gavage. Test groups were administered with doses that ranged from 2034 to 5086 mg/kg bw, with 5 rats in each group (3 male, 2 female). Rats were observed for 14 days after treatment. No mortality was observed in the two lowest dose groups (2034 and 2543 mg/kg bw). Three out of 5 rats died at 3214 and 4069 mg/kg bw, while all rats died in the highest dose group (5086 mg/kg bw). All deaths occurred within 1 day after exposure. Based on these results a LD50 of 3458 mg/kg bw was calculated.
Acute dermal toxicity
Acute dermal toxicity was determined according to a method similar to the OECD 402 guideline. Twenty albino rabbits (10 with abraded, 10 with intact skin, 2x2 rabbits per dose group) were exposed to 321, 455, 641, 905 or 1282 mg/kg bw cinnamon bark oil. Rabbits were observed for 14 days after treatment. No mortality was observed in the three lowest dose groups with intact skin (321, 455 and 641 mg/kg bw). Mortality occurred within 4 days after exposure in all rabbits in the 905 and 1282 mg/kg bw dose groups. Based on these results an LD50 of 702 mg/kg bw was calculated.
Justification for selection of acute toxicity – oral endpoint
The selected study is the key study for this endpoint.
Justification for selection of acute toxicity – dermal endpoint
The selected study is the key study for this endpoint.
Justification for classification or non-classification
Based on the available information, Cinnnamon bark oil has shown to be non-toxic after oral exposure. Therefore, the substance does not need to be classified for acute oral toxicity in accordance with the criteria outlined in Annex I of 1272/2008/EC (CLP/EU-GHS).
Based on the available information, Cinnamon bark oil oil has been shown to be toxic in contact with skin. Therefore, the substance needs to be classified for acute dermal toxicity (Category 3 / H311) according to the criteria outlined in Annex I of 1272/2008/EC (CLP/EU-GHS).
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