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EC number: 943-043-9 | CAS number: 8015-91-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: LD50 = 3458 mg/kg bw (similar to OECD401)
Acute dermal toxicity: LD50 = 702 mg/kg bw (similar to OECD402)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 458 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 702 mg/kg bw
Additional information
Acute oral toxicity
The study was performed according to a method similar to OECD 401. 25 Sherman Wistar (albino) rats (15 male, 10 female) were dosed with varying doses of cinnamon bark oil via oral gavage. Test groups were administered with doses that ranged from 2034 to 5086 mg/kg bw, with 5 rats in each group (3 male, 2 female). Rats were observed for 14 days after treatment. No mortality was observed in the two lowest dose groups (2034 and 2543 mg/kg bw). Three out of 5 rats died at 3214 and 4069 mg/kg bw, while all rats died in the highest dose group (5086 mg/kg bw). All deaths occurred within 1 day after exposure. Based on these results a LD50 of 3458 mg/kg bw was calculated.
Acute dermal toxicity
Acute dermal toxicity was determined according to a method similar to the OECD 402 guideline. Twenty albino rabbits (10 with abraded, 10 with intact skin, 2x2 rabbits per dose group) were exposed to 321, 455, 641, 905 or 1282 mg/kg bw cinnamon bark oil. Rabbits were observed for 14 days after treatment. No mortality was observed in the three lowest dose groups with intact skin (321, 455 and 641 mg/kg bw). Mortality occurred within 4 days after exposure in all rabbits in the 905 and 1282 mg/kg bw dose groups. Based on these results an LD50 of 702 mg/kg bw was calculated.
Justification for classification or non-classification
Based on the available information, the substance does not need to be classified for acute oral toxicity in accordance with the criteria outlined in Annex I of 1272/2008/EC (CLP/EU-GHS).
Based on the available information, the substance needs to be classified for acute dermal toxicity (Category 3 / H311) according to the criteria outlined in Annex I of 1272/2008/EC (CLP/EU-GHS).
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