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Description of key information

The REACH regulation mentions the following for toxicokinetics:  Assessment of the toxicokinetic behaviour of the substance needs to be done to the extent that can be derived from the relevant available information. It is important to note that Iscotrizinol (USAN], Synonym (diethylhexyl butamido triazone) is an organic compound predominantly used in sunscreens to absorb UVA and UVB radiations. 
Thus, the oral ingestion, distribution, metabolism and excretion of the chemical is unlikely. For dermal absorption, certain European studies conducted to review the dermal absorption potential indicate very low degree of percutaneous absorption when the radioactive form of the chemical was used on living human skin samples (ex-vivo).
Analysis of the other toxicity data in the review study conducted on Iscotrizinol led to the conclusion that the compound exhibited a sufficiently high margin of safety.
Thus, the end point of toxico-kinetics was considered for waiver since it can be concluded that the bio-accumulation potential for this chemical is low

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential

Additional information

The REACH regulation mentions the following for toxicokinetics: Assessment of the toxicokinetic behaviour of the substance needs to be done to the extent that can be derived from the relevant available information. It is important to note that Iscotrizinol (USAN], Synonym (diethylhexyl butamido triazone) is an organic compound predominantly used in sunscreens to absorb UVA and UVB radiations.

Thus, the oral ingestion, distribution, metabolism and excretion of the chemical is unlikely. For dermal absorption, certain European studies conducted to review the dermal absorption potential indicate very low degree of percutaneous absorption when the radioactive form of the chemical was used on living human skin samples (ex-vivo).

Analysis of the other toxicity data in the review study conducted on Iscotrizinol led to the conclusion that the compound exhibited a sufficiently high margin of safety.

Thus, the end point of toxico-kinetics was considered for waiver since the bioaccumulation potential of this chemical can be considered to be low.

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