Registration Dossier
Registration Dossier
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EC number: 406-530-2 | CAS number: - MDI
Endpoint summary
Administrative data
Description of key information
Based on the results of two studies in rabbits, the substance is not irritating/corrosive to skin and eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
An in vivo skin irritation study was performed with the substance according to OECD 404 and GLP principles. Three New Zealand White rabbits were exposed to a single (semiocclusive) dose for 4 h. Very slight erythema was observed 50 minutes after bandage removal in one animal. The erythema was reversible within 24 hours after exposure.
An in vivo eye irritation study was performed with the substance according to OECD guideline 405 and GLP principles. Three New Zealand White rabbits were exposed to a single dose. Irritation to the conjunctivae was observed in all three animals. The irritation was fully reversible within 72 hours.
Justification for classification or non-classification
Based on the study results, MDI/CHA/ODA does not have to be classified for skin irritation and eye irritation according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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